Bax induces mitochondria-dependent programed cell death. While cytotoxic drugs activating Bax have been developed for cancer treatment, clinically effective therapeutics suppressing Bax-induced cell death rescuing essential cells have not been developed. This mini-review will summarize previously reported Bax inhibitors including peptides, small compounds, and antibodies. We will discuss potential applications and the future direction of these Bax inhibitors.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6552396 | PMC |
| http://dx.doi.org/10.1177/1535370219833624 | DOI Listing |
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