Introduction: CCH (Collagenase Clostridium Histolyticum; Xiapex) has become established as a simple and reliable alternative to traditional treatments for Dupuytren's contracture. This study aims to analyse our results and discuss our modifications of this therapy.
Patients And Methods: The study included 312 fingers treated with CCH between 2011 and 2018 (256 patients; 225 men and 31 women). There were 157 fingers (50.3 %) with an isolated joint contracture, while multiple joints were affected in 155 fingers (49.7 %). The average age at surgery was 65.8 years. The follow-up period averaged 41.2 weeks. A retrospective data analysis evaluated our results and the effect of our technical modifications on treatment success.
Results: The average presurgical degree of contracture was 63.3 degrees. The average contracture reduction compared to the initial value was 94 % immediately after surgery and 81 % at the last follow-up. There were skin cracks in 22.1 %. The postsurgical course was uneventful in 99.4 %, with minor complications in 0.6 %. The recurrence rate was 14.4 % Extension of the time interval until stretching (24 vs. 48 hours) had no significant effect on the immediate success rate or the rate of skin lesions.
Conclusions: If the indication is chosen correctly and the treatment is performed by an experienced surgeon, the success rate with CCH is comparable to other current treatment options.
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