Twelve dihydrostilbenes (including five new analogues) were prepared by the Witting-Hornor reaction from appropriate aromatic aldehydes and phosphonate esters, followed by hydrogenation in five steps. The inhibition activity against human neutrophil elastase (HNE) of these dihydrostilbenes was evaluated, and three 1,2-dihydroxylated dihydrostilbenes (, , and ) exhibited stronger inhibitory activity against HNE than other analogues.
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| http://dx.doi.org/10.1080/10286020.2019.1571489 | DOI Listing |
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