AI Article Synopsis
- - The research aimed to find sensitive markers for predicting acute kidney allograft rejection (AR) in kidney transplant patients, specifically examining the neutrophil-to-lymphocyte ratio (NLR).
- - A study of 51 kidney transplant patients showed that those with AR had significantly higher NLR values compared to controls, with a cut-off of 2.5 indicating high NLR.
- - The findings suggest that elevated NLR is a strong predictor of AR, proposing it as a simple and effective marker for early detection in kidney transplant recipients.
Article Abstract
Background/aim: Our research focused on the identification of easily available and sensitive markers for early prediction of acute kidney allograft rejection (AR). We aimed to investigate the association between neutrophil-to-lymphocyte ratio (NLR) and AR in kidney transplant patients.
Materials And Methods: The medical records of 51 kidney transplant patients [12 female/39 male; median age of 32 (IQR: 24–44) years] were evaluated retrospectively. We considered a cut-off value of >2.5 as high NLR.
Results: A total of 22 biopsy-proven AR patients and 29 controls were evaluated. The AR group had a higher NLR compared to the controls (P < 0.001). NLR levels over 2.5 [95% CI: 54.88 (9.96–302.3), P < 0.001] were significantly associated with AR in univariate analysis. The NLR levels were the only significant factor associated with AR in multivariate models, in model 1 (adjusted by age and sex) [95% CI: 114 (11.1–1175), P < 0.001], and in model 2 (adjusted by steroid dosage, uric acid, and NLR) [95% CI: 4.60 (1.59–29.3), P = 0.004].
Conclusions: Our data showed that higher NLR values (>2.5) are associated with AR in kidney transplant patients, leading to the conclusion that NLR might be an easily available and useful marker option for detection of AR in this patient population.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7024429 | PMC |
| http://dx.doi.org/10.3906/sag-1811-41 | DOI Listing |
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