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| http://dx.doi.org/10.1128/AAC.00106-19 | DOI Listing |
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High Prevalence of Antimicrobial Resistance Genes in Multidrug-Resistant Extended-Spectrum Beta-Lactamase-Producing Clinical Isolates after COVID-19 Pandemic, North Iran.
Adv Biomed Res
October 2024
Pediatric Infectious Diseases Research Center, Communicable Diseases Institute, Mazandaran University of Medical Sciences, Sari, Iran.
Background: Amid the COVID-19 pandemic, the surge in hospital admissions and widespread use of broad-spectrum antibiotics have heightened the risk of hospital-acquired infections from multidrug-resistant (MDR) organisms, particularly . It is imperative to implement stringent measures to curb the spread of antimicrobial resistance in hospitals and devise robust treatment strategies for patients grappling with such infections. To confront this challenge, a comprehensive study was undertaken to examine MDR extended-spectrum beta-lactamase (MDR-ESBL)-producing isolates from patients with nosocomial infections following the COVID-19 pandemic in Northern Iran.
View Article and Find Full Text PDFIdentification and characterisation of colistin-resistant co-producing IMP-1 and OXA-58 carbapenemases.
New Microbes New Infect
December 2024
Department of Microbiology and Immunology, Teikyo University School of Medicine, Kaga, Itabashi, Tokyo, Japan.
Background: Carbapenem-resistant is of increasing global concern because infections are challenging to treat with standard antibiotics. Here, we identified a previously uncharacterised sp. clinical isolate as co-producing IMP-1 and OXA-58.
View Article and Find Full Text PDFMore than just the gene: investigating expression using a non-native plasmid and host and its impact on resistance conferred by β-lactamase OXA-58 isolated from a hospital wastewater microbiome.
Lett Appl Microbiol
October 2024
School of Pharmacy, Queen's University Belfast, 97 Lisburn Road, Belfast BT9 7BL, United Kingdom.
With the escalation of hospital-acquired infections by multidrug resistant bacteria, understanding antibiotic resistance is of paramount importance. This study focuses on the β-lactamase gene, blaOXA-58, an important resistance determinant identified in a patient-facing hospital wastewater system. This study aimed to characterize the behaviour of the OXA-58 enzyme when expressed using a non-native plasmid and expression host.
View Article and Find Full Text PDFMolecular genotyping reveals multiple carbapenemase genes and unique bla (oxaAb) alleles among clinically isolated Acinetobacter baumannii from a Philippine tertiary hospital.
Trop Med Health
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Pathogen-Host-Environment Interactions Research Laboratory, Institute of Biology, College of Science, University of the Philippines Diliman, 1101, Quezon City, Philippines.
Background: Acinetobacter baumannii continued to be an important Gram-negative pathogen of concern in the clinical context. The resistance of this pathogen to carbapenems due to the production of carbapenemases is considered a global threat. Despite the efforts to track carbapenemase synthesis among A.
View Article and Find Full Text PDFRESIST ACINETO test for the rapid detection of NDM and OXA acquired carbapenemases directly from blood culture in species.
Microbiol Spectr
October 2024
UMR Processus Infectieux en Milieu Insulaire Tropical, CNRS 9192, INSERM U1187, IRD 249, Université de La Réunion, Saint-Denis, La Réunion, France.
Article Synopsis
- Carbapenem-resistant Acinetobacter baumannii (CRAB) is a major global health concern, particularly in bloodstream infections, making early detection vital for effective treatment.
- The RESIST ACINETO immunochromatographic assay accurately detects key carbapenemases (OXA-23, OXA-40/58, NDM) in clinical isolates, demonstrating perfect sensitivity and specificity in both bacterial and blood cultures.
- Utilizing RESIST ACINETO can enhance rapid identification of CRAB in high-incidence regions like the Balkans and Southeast Asia, facilitating optimized treatment strategies, especially with alternatives like cefiderocol.
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