AI Article Synopsis
- * Understanding how nanocarriers interact with the body is crucial for ensuring their safety and effectiveness before they can be approved for clinical use.
- * Advanced Raman imaging techniques, like CARS and SRS, are being developed to study nanocarrier behavior at the single-cell level, offering a way to investigate their action in living tissues.
Article Abstract
The efficacy of pharmaceutical agents can be greatly improved through nanocarrier delivery. Encapsulation of pharmaceutical agents into a nanocarrier can enhance their bioavailability and biocompatibility, whilst also facilitating targeted drug delivery to specific locations within the body. However, detailed understanding of the in vivo activity of the nanocarrier-drug conjugate is required prior to regulatory approval as a safe and effective treatment strategy. A comprehensive understanding of how nanocarriers travel to, and interact with, the intended target is required in order to optimize the dosing strategy, reduce potential off-target effects, and unwanted toxic effects. Raman spectroscopy has received much interest as a mechanism for label-free, non-invasive imaging of nanocarrier modes of action in vivo. Advanced Raman imaging techniques, including coherent anti-Stokes Raman scattering (CARS) and stimulated Raman scattering (SRS), are paving the way for rigorous evaluation of nanocarrier activity at the single-cell level. This review focuses on the development of Raman imaging techniques to study organic nanocarrier delivery in cells and tissues.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6474004 | PMC |
| http://dx.doi.org/10.3390/nano9030341 | DOI Listing |
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