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| http://dx.doi.org/10.3389/fnins.2019.00099 | DOI Listing |
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Exploring memory-related network via dorsal hippocampus suppression.
Netw Neurosci
December 2024
Department of Biomedical Engineering, The Pennsylvania State University, University Park, PA, USA.
Memory is a complex brain process that requires coordinated activities in a large-scale brain network. However, the relationship between coordinated brain network activities and memory-related behavior is not well understood. In this study, we investigated this issue by suppressing the activity in the dorsal hippocampus (dHP) using chemogenetics and measuring the corresponding changes in brain-wide resting-state functional connectivity (RSFC) and memory behavior in awake rats.
View Article and Find Full Text PDFChallenges and opportunities of acquiring cortical recordings for chronic adaptive deep brain stimulation.
Nat Biomed Eng
December 2024
Department of Psychiatry and Behavioral Sciences, University of Minnesota, Minneapolis, MN, USA.
Deep brain stimulation (DBS), a proven treatment for movement disorders, also holds promise for the treatment of psychiatric and cognitive conditions. However, for DBS to be clinically effective, it may require DBS technology that can alter or trigger stimulation in response to changes in biomarkers sensed from the patient's brain. A growing body of evidence suggests that such adaptive DBS is feasible, it might achieve clinical effects that are not possible with standard continuous DBS and that some of the best biomarkers are signals from the cerebral cortex.
View Article and Find Full Text PDFNeurorights Training of a Multidisciplinary Studentship Based on Realistic Neuroscience.
AJOB Neurosci
December 2024
International Center for Neuroscience and Ethics (CINET), Tatiana Foundation.
As is usually the case with other topics addressed by neuroethics, a rigorous analysis of neurorights requires an interdisciplinary approach. In response to this need and in the context of the global expansion of regulatory initiatives on neurorights, we coordinated, under the auspices of the International Center for Neuroscience and Ethics (CINET), an introductory course on neurorights from a neuroscientific perspective. The course, aimed at sixty students from diverse backgrounds (neuroscience, psychology, and law, among others), consisted of a 10-hr training that showed the current approaches and discussions on neurorights and outlined cutting-edge technologies to register, analyze, and manipulate human brain activity from a realistic stance.
View Article and Find Full Text PDFA Method for Assessing Working Memory in Rats Using Controlled Virtual Environment.
Sovrem Tekhnologii Med
December 2024
PhD, Chair in Computational Systems Biology, Center for Biomedical Technology; Universidad Politécnica de Madrid, Madrid, 28223, Spain.
Unlabelled: is to develop an experimental method to effectively assess the working memory in rats. The method uses a state-of-the-art controlled virtual environment with a virtual maze. The setup includes a treadmill for rodents, a fixation system, a dome for displaying virtual environment, and a control unit.
View Article and Find Full Text PDFBiomarker Methodologies: A NIMH Perspective.
Adv Neurobiol
November 2024
National Institutes of Health, National Institute of Mental Health, Rockville, MD, USA.
Biomarkers are critically important in the development of drugs, biologics, medical devices, and psychosocial interventions for psychiatric disorders. As the lead federal agency charged with setting and supporting the national agenda for mental health research, the National Institute of Mental Health (NIMH) funds a broad portfolio of basic, translational, and clinical research focused on identifying, developing, and validating biomarkers for serious mental illnesses and neurodevelopmental conditions. In psychiatric research over the past 10 years, there has been an intensive effort to identify biomarkers as potential tools to improve treatment options for individuals with mental health concerns and increase success in the development of novel interventions.
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