Research in India based on next generation sequencing (NGS) has been plentiful over the past few years. Significant progress in research both in benign and malignant haematology can be attributed to this technique. It has now progressed to both diagnostic and a theranostic modality in many areas of not only haematology but also other medical specialities. Papers presented at the annual conference of the Indian Society of Haematology and Blood Transfusion, ISHBT (Haematocon 2018) highlighted a snapshot of the research activities using NGS that are ongoing in various academic and other centres. This review summarizes the salient findings of the original research abstracts presented. The papers are divided into two broad subsections of non-malignant and malignant haematology.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369091 | PMC |
http://dx.doi.org/10.1007/s12288-018-01068-4 | DOI Listing |
Obes Surg
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Coimbra Institute for Clinical and Biomedical Research (iCBR) Area of Environment, Genetics and Oncobiology (CIMAGO), Faculty of Medicine, University of Coimbra, Coimbra, Portugal.
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View Article and Find Full Text PDFNat Methods
January 2025
Broad Institute of MIT and Harvard, Cambridge, MA, USA.
A key challenge of the modern genomics era is developing empirical data-driven representations of gene function. Here we present the first unbiased morphology-based genome-wide perturbation atlas in human cells, containing three genome-wide genotype-phenotype maps comprising CRISPR-Cas9-based knockouts of >20,000 genes in >30 million cells. Our optical pooled cell profiling platform (PERISCOPE) combines a destainable high-dimensional phenotyping panel (based on Cell Painting) with optical sequencing of molecular barcodes and a scalable open-source analysis pipeline to facilitate massively parallel screening of pooled perturbation libraries.
View Article and Find Full Text PDFSci Rep
January 2025
General Surgery Department, Jiangsu University Affiliated People's Hospital, Zhenjiang, 212000, China.
Crohn's disease (CD) is a chronic inflammatory bowel disease with an unknown etiology. Ubiquitination plays a significant role in the pathogenesis of CD. This study aimed to explore the functional roles of ubiquitination-related genes in CD.
View Article and Find Full Text PDFCardiovasc Intervent Radiol
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Department of Radiology, Johns Hopkins University, Baltimore, MD, USA.
Sci Rep
January 2025
Department of Control Science and Engineering, Harbin Institute of Technology, Harbin, 150001, China.
As a multivariate time series, the prediction of curling trajectories is crucial for athletes to devise game strategies. However, the wide prediction range and complex data correlations present significant challenges to this task. This paper puts forward an innovative deep learning approach, CasLSTM, by introducing integrated inter-layer memory, and establishes an encoder-predictor curling trajectory forecasting model accordingly.
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