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The preferential effect of Clemastine on F3/Contactin-1/Notch-1 compared to Jagged-1/Notch-1 justifies its remyelinating effect in an experimental model of multiple sclerosis in rats.
Int Immunopharmacol
February 2024
Department of Pharmacology and Toxicology, Faculty of Pharmacy, Cairo University, Cairo, Egypt; Biology Department, School of Pharmacy, Newgiza University, Giza, Egypt.
Clemastine (CLM) is repurposed to enhance remyelination in multiple sclerosis (MS) patients. CLM blocks histamine and muscarinic receptors as negative regulators to oligodendrocyte differentiation. These receptors are linked to the canonical and non-canonical Notch-1 signaling via specific ligands; Jagged-1 and F3/Contactin-1, respectively.
View Article and Find Full Text PDFMachine learning-based biomarker profile derived from 4210 serially measured proteins predicts clinical outcome of patients with heart failure.
Eur Heart J Digit Health
December 2023
Department of Cardiology, Erasmus MC, University Medical Center Rotterdam, Dr. Molenwaterplein 40, 3015GD, Rotterdam, The Netherlands.
Aims: Risk assessment tools are needed for timely identification of patients with heart failure (HF) with reduced ejection fraction (HFrEF) who are at high risk of adverse events. In this study, we aim to derive a small set out of 4210 repeatedly measured proteins, which, along with clinical characteristics and established biomarkers, carry optimal prognostic capacity for adverse events, in patients with HFrEF.
Methods And Results: In 382 patients, we performed repeated blood sampling (median follow-up: 2.
Increased frequency of CD39CD73 regulatory T cells and Deltex-1 gene expression level in kidney transplant recipients with excellent long-term graft function.
Transpl Immunol
June 2023
Immunoregulation Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran; Department of Immunology, School of Medicine, Babol University of Medical Sciences, Babol, Iran. Electronic address:
Background: The ability of regulatory T cells (Tregs) to limit inflammatory responses has been demonstrated. However, different subpopulations of this cell have varying abilities to suppress alloreactive immune responses. The primary goal of this study was to assess the frequency of CD4FOXP3CD39CD73 Tregs and Deltex-1 gene expression on long-term renal transplant function.
View Article and Find Full Text PDFDeltex1 suppresses T cell function and is a biomarker for diagnosis and disease activity of systemic lupus erythematosus.
Rheumatology (Oxford)
April 2019
Department of Medicine, National Yang-Ming University, Taiwan.
Deltex1 suppresses T cell function and is a biomarker for diagnosis and disease activity of systemic lupus erythematosus.
Rheumatology (Oxford)
April 2019
Department of Medicine, National Yang-Ming University, Taiwan.
Objective: Deletion of Deltex1 (DTX1) in mice caused hyperactivation of T cells and lupus-like autoimmune syndromes, however, the association of DTX1 with human autoimmune diseases is totally unknown. This study investigated the role of DTX1 in human T cell functions and its correlation with disease activity in patients with SLE.
Methods: The influence of DTX1 on T cell function was evaluated using human primary cells.
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