Microimplants are being used extensively in clinical practice to achieve absolute anchorage. Success of microimplant mainly depend on its primary stability onto the cortical bone surface and the associated Microdamage of the cortical bone during insertion procedure leads to many a microimplants to fail and dislodge from the cortical bone leading to its failure. Even though, previous studies showed occurrence of microdamage in the cortical bone, they were mainly 2-dimension studies or studies that were invasive to the host. In the present study, we used a non-invasive, non-ionizing imaging technique- Optical Coherence Tomography (OCT), to image and analyze the presence of microdamage along the cortical bone surrounding the microimplant. We inserted 80 microimplants in two different methods (drill and drill free method) and in two different angulations onto the cortical bone surface. Images were obtained in both 2D and 3D imaging modes. In the images, microdamage in form of microcracks on the cortical bone surface around the bone-microimplant interface and micro-elevations of the cortical bone in angulated microimplant insertions and the presence of bone debris due to screwing motion of the microimplant on insertion can be appreciated visually and quantitatively through the depth intensity profile analysis of the images.
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http://dx.doi.org/10.1038/s41598-019-39670-9 | DOI Listing |
Although the toxic effect of Sedentary behavior (SED) on bone health has been demonstrated in the previous study, the underlying mechanisms of SED, or break SED to bone health remain unclear. In this study, we aim to investigate the effects of sedentary behavior (SED) on bone health, as well as the potential favor effects of moderate to vigorous physical activity (MVPA) and periodic interruptions of SED. To simulate SED, we used small Plexiglas cages (20.
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Center for Musculoskeletal Research, University of Rochester, School of Medicine and Dentistry, Rochester, NY, USA.
The cranial mesenchyme, originating from both neural crest and mesoderm, imparts remarkable regional specificity and complexity to postnatal calvarial tissue. While the distinct embryonic origins of the superior and dura periosteum of the cranial parietal bone have been described, the extent of their respective contributions to bone and vessel formation during adult bone defect repair remains superficially explored. Utilizing transgenic mouse models in conjunction with high-resolution multiphoton laser scanning microscopy (MPLSM), we have separately evaluated bone and vessel formation in the superior and dura periosteum before and after injury, as well as following intermittent treatment of recombinant peptide of human parathyroid hormone (rhPTH), Teriparatide.
View Article and Find Full Text PDFChem Pharm Bull (Tokyo)
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Drug Discovery Research Department, Kyoto Pharmaceutical Industries, Ltd.
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View Article and Find Full Text PDFJ Oral Biosci
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Bioceramics Group, Research Center for Macromoleclules and Biomaterials, National Institute for Materials Science, Tsukuba, Japan. Electronic address:
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J Orthop Case Rep
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Department of Orthopedics, Stanley Medical College, Chennai, Tamil Nadu, India.
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