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35kDa SPECIFIC-SIZED HYALURONAN AMELIORATES HIGH-FAT DIET-INDUCED LIVER INJURY IN MURINE MODEL OF MODERATE OBESITY.
Matrix Biol
December 2024
Department of Inflammation and Immunity, Cleveland Clinic, Cleveland, OH; Department of Molecular Medicine, Case Western Reserve University, Cleveland, OH. Electronic address:
Obesity is a growing concern in the US and world-wide, associated with an increased risk for several cardiometabolic diseases, including metabolic associated steatotic liver disease (MASLD). Currently, therapeutic interventions to prevent and/or treat MASLD are limited, and research is needed to identify new therapeutic targets. The specific-sized 35kDa fragment of hyaluronan (HA35), has gut protective and anti-inflammatory properties and a previous pilot clinical study reported it is well tolerated in healthy individuals.
View Article and Find Full Text PDFReduction of Hepatic Fat Content by Dulaglutide for the Treatment of Diabetes Mellitus: A Two-Centre Open, Single-Arm Trial.
Endocrinol Diabetes Metab
January 2025
Department of Hematology, Affiliated Hospital of Qingdao University, Qingdao, China.
Background: With the elevated level of NAFLD prevalence, the incidence of diabetes, hypertension, metabolic syndrome and other diseases is also significantly elevated. GLP-1RA can exert weight loss, glucose-lowering effects and various nonglycaemic effects. However, the relationship between quantitative reduction in hepatic fat content and improvement of pancreatic islet function by GLP-1RA is unclear.
View Article and Find Full Text PDFAssociation between FTO gene polymorphism and obesity in down syndrome children.
Eur J Pediatr
December 2024
Department of Clinical Pathology Faculty of Medicine, Mansoura University, Mansoura, Egypt.
Unlabelled: Children with Down syndrome (DS) have a higher incidence of overweight and obesity compared to typically developing peers. The fat mass and obesity-associated gene (FTO) is one of the early identified genes linked to obesity in various populations. To date, the FTO rs17817449 gene polymorphism has not been investigated in overweight/obese-DS (ODS) individuals.
View Article and Find Full Text PDFThe impact of Mayo Adhesion probability score on the success of extracorporeal shock wave lithotripsy for kidney stones.
Urolithiasis
December 2024
Department of Urology, Haseki Training and Research Hospital, Istanbul, Turkey.
Urolithiasis is a prevalent condition in urology, with extracorporeal shock wave lithotripsy (ESWL) serving as a common treatment for kidney stones under 2 cm. The Mayo Adhesion Probability (MAP) score, calculated from perinephric fat characteristics, is traditionally used to assess surgical outcomes but has not been explored in the context of ESWL. This study aims to evaluate the effect of MAP score on the success rate of ESWL.
View Article and Find Full Text PDFInfiltration of micro-fragmented adipose tissue under local anesthesia for knee osteoarthritis treatment is a safe procedure: A case series.
Clinics (Sao Paulo)
December 2024
Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (HC-FMUSP), São Paulo, SP, Brazil.
Article Synopsis
- Knee osteoarthritis is becoming more common due to aging and obesity, and biological therapies like microfragmented Adipose Tissue (mFAT) injections may help improve patient outcomes.
- A study evaluated the safety of harvesting adipose tissue and injecting mFAT in 34 patients under local anesthesia, observing them during the procedure and one week later.
- Results showed only minor issues like ecchymosis and mild discomfort, with no significant adverse events reported, indicating the procedure is safe.
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