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Intoxications involving methoxyacetylfentanyl and U-47700: a study of 3 polydrug fatalities.
Int J Legal Med
September 2024
Institute of Forensic Medicine, Forensic Toxicology, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Novel synthetic opioids (NSOs) represent an emerging group of novel psychoactive substances, acting as agonists at the opioid receptors. NSOs include fentanyl-related compounds, e.g.
View Article and Find Full Text PDFCombination administration of alprazolam and N-Ethylmaleimide synergistically enhances sleep behaviors in mice with no potential CNS side effects.
PeerJ
May 2024
State Key Laboratory of NBC Protection for Civilian, Beijing, China.
Background: N-Ethylmaleimide (NEM), an agonist of the potassium chloride cotransporters 2 (KCC2) receptor, has been correlated with neurosuppressive outcomes, including decreased pain perception and the prevention of epileptic seizures. Nevertheless, its relationship with sleep-inducing effects remains unreported.
Objective: The present study aimed to investigate the potential enhancement of NEM on the sleep-inducing properties of alprazolam (Alp).
Drug consumption of suspected drug-influenced drivers in Hungary (2016-2018).
Forensic Sci Int
July 2022
Department of Forensic Medicine, Faculty of Medicine, University of Szeged, Szeged, Hungary. Electronic address:
Article Synopsis
- Driving under the influence of drugs (DUID) is risky and depends on when you take them, how much, and how they interact with other drugs.
- A study in Hungary from 2016 to 2018 found that 95% of drivers tested positive for at least one drug, with cannabis and amphetamines being the most common.
- Many drivers showed signs of being impaired (69%), and there were changes in drug use patterns, including a decrease in new psychoactive substances and an increase in synthetic cannabinoids.
Population-based signals of benzodiazepine drug interactions associated with unintentional traumatic injury.
J Psychiatr Res
July 2022
Center for Pharmacoepidemiology Research and Training, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, PA, USA; Department of Biostatistics, Epidemiology, and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Leonard Davis Institute of Health Economics, University of Pennsylvania, Philadelphia, PA, USA. Electronic address:
Benzodiazepine receptor agonists and related medications, such as Z-drugs and dual orexin receptor antagonists (BZDs), have been associated with unintentional traumatic injury due to their central nervous system (CNS)-depressant effects. Drug-drug interactions (DDIs) may contribute to the known relationship between BZD use and unintentional traumatic injury, yet evidence is still lacking. We conducted high-throughput pharmacoepidemiologic screening using the self-controlled case series design in a large US commercial health insurance database to identify potentially clinically relevant DDI signals among new users of BZDs.
View Article and Find Full Text PDFFrom 2000 to 2014, drug overdose deaths increased 137% in the United States, and 61% of these deaths included some form of opiate. The vast majority of opiate-related drug fatalities include multiple drugs, although there is scant data quantitatively describing the exact drugs that contribute to deaths due to multiple drugs. In the present study, we sought to quantitatively identify the drugs that occur with opiates in accidental multidrug-related fatalities.
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