Purpose: The ethanol extracts from seven Thai plants, Kaempferia parviflora, Stemona tuberosa Lour., Ananas comosus, Punica granatum, Musa sapientum L., Pseuderanthemum palatiferum and Annona muricata L., which are traditionally used in Thailand to support human health, were evaluated for their anti-Plasmodium and anti-Toxoplasma activities, and for their cytotoxicities against human foreskin fibroblasts in vitro.
Results: The K. parviflora, P. palatiferum and A. muricata extracts were active against P. falciparum (3D7) with selectivity index (SI) values > 10, while their half maximal inhibitory concentrations (IC50) were 28.7 µg/ml, 78.8 µg/ml and 46.1 µg/ml, respectively. Extracts from K. parviflora and M. sapientum (ripe fruit peel) inhibited T. gondii (RH) growth with IC50 values of 53.5 µg/ml and 90.4 µg/ml, respectively. The SI values of the extracts from K. parviflora and M. sapientum (ripe fruit peel) were 9.0 and 10.8, respectively.
Conclusion: Our data show that some of the aforementioned ethanol extracts are potential sources of new drugs to treat Plasmodium and Toxoplasma infections.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.2478/s11686-019-00036-w | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Antioxidant, Antimicrobial, Anticancer, and Molecular Docking Insights into Pancratium maritimum Seeds and Flowers: A Phytochemical Approach.
ChemistryOpen
January 2025
Department of Biochemistry and Molecular Biology, Federal University of Santa Maria, Santa Maria, Brazil.
This study investigates the antioxidant, antimicrobial, and anticancer properties of Pancratium maritimum L. in Sp. Pl.
View Article and Find Full Text PDFUrban parks biowaste as a sustainable source of new antidiabetics.
Acta Pharm
December 2024
University of Zagreb Faculty of Pharmacy and Biochemistry, Department of Pharmacognosy 10000 Zagreb, Croatia.
Biowaste produced in urban parks is composed of large masses of organic matter that is only occasionally used economically. In this work, extracts of six plants widely distributed in urban parks in Central Europe (, , , , , and ), prepared using 10 % and 50 % ethanol, were screened for their antidiabetic and related properties. HPLC and UV-Vis analysis revealed the presence of caffeic acid, quercetin, luteolin, and apigenin derivatives.
View Article and Find Full Text PDFAngelica gigas Nakai (Korean Dang-gui) Root Alcoholic Extracts in Health Promotion and Disease Therapy - active Phytochemicals and In Vivo Molecular Targets.
Pharm Res
January 2025
Penn State Cancer Institute, Pennsylvania State University, Hershey, PA, 17033, USA.
Angelica gigas Nakai (AGN) root is a medicinal herbal widely used in traditional medicine in Korea. AGN root ethanolic extracts have been marketed as dietary supplements in the United States for memory health and pain management. We have recently reviewed the pharmacokinetics (PK) and first-pass hepatic metabolism of ingested AGN supplements in humans for the signature pyranocoumarins decursin (D, C 1x), decursinol angelate (DA, C ~ 10x) and their common botanical precursor and hepatic metabolite decursinol (DOH, C ~ 1000x).
View Article and Find Full Text PDFMicrobial production of food lipids using the oleaginous yeast Apiotrichum brassicae.
Food Res Int
January 2025
VTT Technical Research Centre of Finland, Tekniikantie 21, 02044 VTT Espoo, Finland. Electronic address:
Oleaginous yeasts offer a promising sustainable alternative for producing edible lipids, potentially replacing animal and unsustainable plant fats and oils. In this study, we screened 11 oleaginous yeast species for their lipid profiles and identified Apiotrichum brassicae as the most promising candidate due to its versatility across different growth media. A.
View Article and Find Full Text PDFTailored recovery of antioxidant fractions enriched in caffeine and phenolic compounds from coffee pulp using ethanol-modified supercritical carbon dioxide.
Food Res Int
January 2025
Department of Agricultural Chemistry and Food Science, Faculty of Science, C/ Francisco Tomás y Valiente, 7, Universidad Autónoma de Madrid, 28049 Madrid, Spain; Department of Production and Characterization of Novel Foods, Institute of Food Science Research, CIAL (UAM-CSIC), 28049 Madrid, Spain. Electronic address:
Coffee pulp (CP) is the by-product of coffee processing that urgently needs to be revalorized using sustainable technologies. This work applied a design of experiment (DoE) for modeling the extraction of bioactive compounds from CP using supercritical carbon dioxide (sc-CO) with ethanol as a co-solvent under variable conditions (temperature, pressure, and ethanol percentage). Considering extraction efficiency (per unit of CP) and extraction selectivity (per unit of extract), results showed that ethanol percentage significantly enhanced the efficiency of total phenolic content, as well as the selectivity of chlorogenic acid and protocatechuic acid (p < 0.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!