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Expression of semaphorin-3A in the joint and role in osteoarthritis.
Cell Biochem Funct
April 2024
Department of Comparative Biomedical Sciences, Royal Veterinary College, London, UK.
Article Synopsis
- Osteoarthritis (OA) involves joint cartilage degradation and pain, and the study explores the role of semaphorin-3A (sema-3A) in this process.
- Sema-3A is found in various joint tissues, with increased expression in highly innervated areas under mechanical stress and decreased in cartilage during severe OA.
- The research indicates that sema-3A may influence both the innervation of painful joint tissues and the degeneration of cartilage by affecting chondrocyte differentiation.
Effects of letrozole on serum estradiol and estrone in postmenopausal breast cancer patients and tolerability of treatment: a prospective trial using a highly sensitive LC-MS/MS (liquid chromatography-tandem mass spectrometry) method for estrogen measurement.
Breast Cancer Res Treat
October 2023
Comprehensive Cancer Center, Helsinki University Hospital, PO Box 180, 00290, Helsinki, Finland.
Article Synopsis
- The study examined the levels of serum estradiol (E2) and estrone (E1) in postmenopausal breast cancer patients undergoing letrozole treatment and investigated how these hormones relate to quality of life (QoL) and side effects.
- Out of 100 patients screened, 90 completed the trial, revealing that letrozole effectively suppressed E2 and E1 levels, while side effects like joint pain and muscle aches increased during treatment.
- The findings indicate that high baseline E2 levels were linked to increased joint and muscle pain, and highlight that traditional immunoassays are not effective for monitoring E2 during letrozole therapy due to sensitivity issues.
Improving clinical outcomes of Barrett's esophagus with high dose proton pump inhibitors and cryoablation.
Ann Med
December 2023
Department of Internal Medicine, RWJBarnabas Health Jersey City Medical Center, Jersey City, NJ, USA.
Introduction: Esophageal adenocarcinoma incidence has increased significantly despite surveillance endoscopy for Barrett's esophagus (BE) and gastric acid supression medications. This prospective, cohort study's aims were to determine the long-term efficacy of proton-pump inhibitors twice daily (PPI-BID) with cryotherapy (CRYO) for complete ablation of BE.
Materials And Methods: Consecutive BE patients were managed with a PPI-BID, CRYO ablation, follow-up protocol.
Melatonin and Health: Insights of Melatonin Action, Biological Functions, and Associated Disorders.
Cell Mol Neurobiol
August 2023
Department of Clinical Pharmacy, College of Pharmacy, King Saud University, Riyadh, 11451, Saudi Arabia.
Melatonin is ubiquitous molecule with wide distribution in nature and is produced by many living organisms. In human beings, pineal gland is the major site for melatonin production and to lesser extent by retina, lymphocytes, bone marrow, gastrointestinal tract, and thymus. Melatonin as a neurohormone is released into circulation wherein it penetrates all tissues of the body.
View Article and Find Full Text PDFEffects of buprenorphine on model development in an adjuvant-induced monoarthritis rat model.
PLoS One
February 2022
Dept. of Experimental Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Complete Freund's adjuvant (CFA)-induced arthritis in rats is a common animal model for studying chronic inflammatory pain. However, modelling of the disease is associated with unnecessary pain and impaired animal wellbeing, particularly in the immediate post-induction phase. Few attempts have been made to counteract these adverse effects with analgesics.
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