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McArdle sign and neck flexion-induced change in central motor conduction in multiple sclerosis.
Mult Scler
December 2024
Department of Neurology, Mayo Clinic, Rochester, MN, USA.
Article Synopsis
- * Researchers measured central motor conduction time (CMCT) in different groups, including MS patients with and without the McArdle sign, other myelopathy patients, and healthy controls.
- * Results showed that MS patients with a prominent McArdle sign displayed significantly prolonged CMCT during neck flexion, suggesting that the sign may be linked to nerve conduction slowing due to demyelination.
Phenotypic, Electrophysiologic, and Imaging Spectrum of Hirayama Disease from Northern India.
Ann Indian Acad Neurol
September 2024
Department of Neurology, All India Institute of Medical Sciences, New Delhi, India.
Background And Objectives: Cervical flexion-induced myelopathy, also known as Hirayama disease (HD), is a lower motor neuron disorder seen mainly in adolescents and young adults, affecting the C7-T1 myotomes, presenting as asymmetric weakness with wasting of one or both the distal upper limbs. We aimed to describe the clinical features, electrophysiology, and radiologic features of HD in a tertiary care institute in northern India.
Methods: One hundred and forty patients between 2017 and 2022 with clinical and imaging features consistent with HD were retrospectively reviewed from the All India Institute of Medical Sciences-Comprehensive Neuromuscular Diseases center database.
Monomelic Amyotrophy/Hirayama Disease: Surgical Outcome in a Large Cohort of Indian Patients.
World Neurosurg
March 2024
Department of Neurology, National Institute of Mental Health and Neuro Sciences, Bengaluru, Karnataka, India. Electronic address:
Background: Hirayama disease (HD) is a cervical compressive myelopathy. Anterior cervical discectomy and fusion (ACDF) is identified as the best surgical approach. We evaluated surgical outcomes and factors influencing ACDF in HD.
View Article and Find Full Text PDFMcArdle Sign: A Specific Sign of Multiple Sclerosis.
Mayo Clin Proc
August 2019
Department of Neurology, Mayo Clinic, Rochester, MN. Electronic address:
Objective: To measure McArdle sign (rapidly reversible weakness induced by neck flexion) both qualitatively and quantitatively and to evaluate its specificity and clinical utility for diagnosis of multiple sclerosis (MS).
Patients And Methods: In this prospective study, McArdle sign was evaluated by a technician blinded to diagnosis by measuring changes in finger extensor strength in successive trials of neck extension and flexion, first clinically and then with a torque measurement device. We studied 25 healthy controls and 81 patients with finger extensor weakness.
Flexion-Induced Cervical Cord Compression: Hirayama Disease.
Balkan Med J
May 2019
Department of Physical Medicine and Rehabilitation, Medipol University School of Medicine, İstanbul, Turkey
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