AI Article Synopsis
- Sarcoidosis is a complex disease with uncertain causes, and this study aimed to analyze the lung microbiota of sarcoidosis patients compared to those with other interstitial lung diseases (ILD) and healthy individuals.
- 31 patients with sarcoidosis and 19 with ILD underwent bronchoscopy for fluid collection, followed by gene sequencing to study their pulmonary microbiota, aiming to identify any significant differences.
- Results indicated no notable differences in microbiome composition or diversity between sarcoidosis patients and those with other ILDs, suggesting that while the microbiota may not be significantly altered, it does not rule out its possible role in sarcoidosis development.
Article Abstract
Background: Sarcoidosis is a systemic disease of unknown etiology. The disease mechanisms are largely speculative and may include the role microbial patterns that initiate and drive an underlying immune process. The aim of this study was to characterize the microbiota of the lung of patients with sarcoidosis and compare its composition and diversity with the results from patients with other interstitial lung disease (ILD) and historic healthy controls.
Methods: Patients (sarcoidosis, n = 31; interstitial lung disease, n = 19) were recruited within the PULMOHOM study, a prospective cohort study to characterize inflammatory processes in pulmonary diseases. Bronchoscopy of the middle lobe or the lingula was performed and the recovered fluid was immediately sent for analysis of the pulmonary microbiota by 16sRNA gene sequencing. Subsequent bioinformatic analysis was performed to compare the groups.
Results: There were no significant differences between patients with sarcoidosis or other ILDs with regard to microbiome composition and diversity. In addition, the abundance of the genera Atopobium, Fusobacterium, Mycobacterium or Propionibacterium were not different between the two groups. There were no gross differences to historical healthy controls.
Conclusion: The analysis of the pulmonary microbiota based on 16sRNA gene sequencing did not show a significant dysbiosis in patients with sarcoidosis as compared to other ILD patients. These data do not exclude a microbiological component in the pathogenesis of sarcoidosis.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6396534 | PMC |
| http://dx.doi.org/10.1186/s12931-019-1013-2 | DOI Listing |
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