Background/aims: The present study aimed to investigate the serum levels of adiponectin (APN) and adiponectin receptor 1 (AdipoR1) in patients with type 2 diabetes mellitus (T2DM) combined with macrovascular complications (MVC), as well as their correlation with clinical parameters.
Methods: A total of 60 T2DM patients were divided into 2 groups according to the presence of MVC: T2DM + MVC group (n=30) and T2DM group (n=30). Additionally, 30 healthy people were selected as control group (NC group). Clinical data and biological parameters were detected and recorded. T test was performed to compare the differences between two groups, and the results were corrected using Bonferroni method. Meanwhile, the correlation analysis and multiple stepwise regression analysis were used to analyze the association of APN and AdipoR1 with clinical factors.
Results: The levels of APN and AdipoR1 were significantly decreased in T2DM group and T2DM + MVC group compared with NC group, with the lowest value in T2DM + MVC group (all P<0.01). Serum APN levels were positively correlated with FINS and TG (r = 0.412, 0.316, respectively; both P<0.05), and negatively correlated with SBP, DBP and LDL-C (r = -0.292, -0.383, -0.334, respectively; all P<0.05). Serum levels of AdipoR1 were positively correlated with APN (r = 0.726, P<0.01), and negatively correlated with BMI, SBP, DBP, FBG, TC and LDL-C (r = -0.440, -0.446, -0.374, -0.444, -0.344, -0.709, respectively; all P<0.01).
Conclusion: Serum levels of APN and AdipoR1 are significantly lower in T2DM group and T2DM + MVC group, showing lowest value in T2DM + MVC group. APN and AdipoR1 levels may influence glucose and lipid metabolism in T2DM patients.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.33594/000000016 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Unveiling the Predictive Model for Macrovascular Complications in Type 2 Diabetes Mellitus: microRNAs Expression, Lipid Profile, and Oxidative Stress Markers.
Int J Mol Sci
November 2024
Department of Biochemistry and Molecular Biology I, Faculty of Science, University of Granada, 18071 Granada, Spain.
Article Synopsis
- This study analyzed new circulating markers related to macrovascular complications (MVC) in patients with type 2 diabetes mellitus (T2DM) by comparing controls, patients with T2DM, and those with T2DM and vascular complications.
- Results showed significant differences in the expression of specific microRNAs (miRs) between groups, particularly in miR-126a-3p, which was decreased in patients with vascular complications.
- The study identified predictive models using various biomarkers, including HbA1c, creatinine, total cholesterol, and specific miRs, suggesting new avenues for understanding and predicting MVC in individuals with T2DM.
SUBCLINICAL HYPOTHYROIDISM AS A CONTRIBUTOR TO MACROVASCULAR COMPLICATIONS IN PATIENTS WITH TYPE 2 DIABETES MELLITUS.
Acta Clin Croat
February 2022
1Department of Functional and Laboratory Diagnostics, I Horbachevsky Ternopil National Medical University, Ternopil, Ukraine; 2Department of Pediatrics N2, I Horbachevsky Ternopil National Medical University, Ternopil, Ukraine.
This study aimed to evaluate changes of the lipid panel data in patients with comorbid type 2 diabetes mellitus (T2DM) and subclinical hypothyroidism (SCH) and to identify the probable prognostic values of the lipid profile for macrovascular complication (MVC) development. The study included 370 patients presented with only T2DM and 30 patients suffering from both T2DM and SCH. Receiver operating characteristic (ROC) analysis was used to identify prognostically significant values of the lipid profile with the optimal ratio of sensitivity and specificity for MVC development.
View Article and Find Full Text PDFMuscle fatigability in patients with type 2 diabetes: relation with long-term complications.
Diabetes Metab Res Rev
February 2020
Department of Clinical and Molecular Medicine, La Sapienza University, and Diabetes Unit, Sant'Andrea University Hospital, Rome, Italy.
Aims: It is unclear whether long-term complications play a role in muscle fatigue characteristic of patients with type 2 diabetes mellitus (T2DM). The purpose of this study was to investigate the association between muscle fatigability and microvascular and macrovascular complications in patients with T2DM.
Methods: One-hundred forty-six patients with T2DM (80 males, 66 females, aged 66.
RED CELL DISTRIBUTION WIDTH AND ACUTE COMPLICATIONS OF DIABETES.
Acta Endocrinol (Buchar)
January 2018
Gebze Government Hospital, Dept. of Internal Medicine, Izmit, Turkey.
Context: Red cell distribution width (RDW) has been associated with type 2 diabetes (T2DM), however data in relation to diabetic ketoacidosis (DKA) and hyperglycemic hyperosmolar non-ketotic acidosis (HONK) remains unclear.
Objective: The aim of this study was to evaluate the association between RDW, MCV, and RDW/MVC values and acute complications in T2DM.
Patients And Methods: RDW was measured in 90 T2DM patients (30 DKA, 30 HONK and 30 T2DM without acute complications).
The Effects of Adiponectin and Adiponectin Receptor 1 Levels on Macrovascular Complications Among Patients with Type 2 Diabetes Mellitus.
Cell Physiol Biochem
March 2019
Department of Medical Records, Cangzhou Central Hospital, Cangzhou, China.
Background/aims: The present study aimed to investigate the serum levels of adiponectin (APN) and adiponectin receptor 1 (AdipoR1) in patients with type 2 diabetes mellitus (T2DM) combined with macrovascular complications (MVC), as well as their correlation with clinical parameters.
Methods: A total of 60 T2DM patients were divided into 2 groups according to the presence of MVC: T2DM + MVC group (n=30) and T2DM group (n=30). Additionally, 30 healthy people were selected as control group (NC group).
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!