AI Article Synopsis
- Methicillin-resistant Staphylococcus aureus (MRSA) causes persistent infections by forming biofilms on various surfaces, including medical devices.
- A study tested four surfactants, finding that polysorbate 80 (PS80) effectively inhibits biofilm formation by preventing bacterial adhesion, while being less toxic to cells.
- PS80 showed positive results on plastic, silicon, and dermal tissues, but negative on stainless steel, suggesting its potential use in clinical settings for cleaning wounds and preparing catheters to prevent MRSA infections.
Article Abstract
Methicillin-resistant Staphylococcus aureus (MRSA) forms biofilms on necrotic tissues and medical devices, and causes persistent infections. Surfactants act on biofilms, but their mode of action is still unknown. If used in the clinic, cytotoxicity in tissues should be minimized. In this study, we investigated the inhibitory effect of four different surfactants on MRSA biofilm formation, and found that a nonionic surfactant, polysorbate 80 (PS80), was the most suitable. The biofilm inhibitory effects resulted from the inhibition of bacterial adhesion to substrates rather than biofilm disruption, and the effective dose was less cytotoxic for 3T3 fibroblasts. However, the effects were substrate-dependent: positive for plastic, silicon, and dermal tissues, but negative for stainless-steel. These results indicate that PS80 is effective for prevention of biofilms formed by MRSA on tissues and foreign bodies. Therefore, PS80 could be used in medical practice as a washing solution for wounds and/or pretreatment of indwelling catheters.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6395670 | PMC |
| http://dx.doi.org/10.1038/s41598-019-39997-3 | DOI Listing |
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