Mutations in B gene have been reported in ethambutol (EMB) resistance () isolates. The aim of this study was survey on B 306 and 406 EMB resistant isolated from patients in West of Iran (2014-2015). Fifty strains of from patients with pulmonary tuberculosis (TB) were considered. Drug susceptibility using proportional method was performed. Polymerase chain reaction (PCR) -DNA sequencing was applied for mutation in B 306 and 406 codon detection. Data were analyzed in SPSS 16 software using descriptive statistics and Fisher's exact test (p<0.05). In this study 7 (14%) isolates were resistant to EMB. 6 (85.71%) and 1 (14.28%) resistant isolates had B 306 and 304 codon mutations, respectively. Between embB306 mutations and resistance to EMB and MDR isolates had a significant relationship (p<0.001). The data indicated that B 306 mutations have effect on EMB resistant. Detection of EMB resistant and these mutations prominent for antibiotic prescription.
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| http://dx.doi.org/10.14196/mjiri.32.117 | DOI Listing |
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