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Smectite as a Preventive Oral Treatment to Reduce Clinical Symptoms of DSS Induced Colitis in Balb/c Mice.
Int J Mol Sci
August 2021
Institute of Medical Microbiology, Virology and Hygiene, University Medicine Rostock, 18057 Rostock, Germany.
Natural smectites have demonstrated efficacy in the treatment of diarrhea. The present study evaluated the prophylactic effect of a diosmectite (FI5pp) on the clinical course, colon damage, expression of tight junction (TJ) proteins and the composition of the gut microbiota in dextran sulfate sodium (DSS) colitis. Diosmectite was administered daily to Balb/c mice from day 1 to 7 by oral gavage, followed by induction of acute DSS-colitis from day 8 to 14 ("Control", n = 6; "DSS", n = 10; "FI5pp + DSS", n = 11).
View Article and Find Full Text PDFSmectite clay minerals reduce the acute toxicity of quaternary alkylammonium compounds towards potentially pathogenic bacterial taxa present in manure and soil.
Sci Rep
September 2020
Institute of Soil Sciences and Soil Conservation, iFZ Research Centre for Biosystems, Land Use and Nutrition, Justus Liebig University, Heinrich-Buff-Ring 26-32, 35392, Gießen, Germany.
Article Synopsis
- Quaternary alkylammonium compounds (QAACs) are cationic surfactants used as disinfectants in various industries, and their environmental impact is a concern due to their release into soil.
- A study investigated how expandable layer silicates like smectite and kaolinite affect the bacterial growth responses to two QAACs, BAC-C12 and DADMAC-C10, focusing on minimal inhibitory concentrations (MICs) across different bacterial strains.
- Results showed that smectite increased the MIC values for the bacteria tested, indicating that it can mitigate QAAC toxicity, while kaolinite had no significant effect; this suggests that soil properties can influence bacterial resilience to toxic compounds.
Smectite for acute infectious diarrhoea in children: A Cochrane review summary.
Int J Nurs Stud
June 2021
Clinical Nurse and Early Career Research Fellow, Skin Integrity Service, Royal Brisbane and Women's Hospital, Brisbane Australia; Joint Appointment with School of Nursing, Queensland University of Technology, Kelvin Grove Australia; Level 2, Building 34, Centre for Clinical Nursing, Royal Brisbane and Women's Hospital, Herston, Queensland, 4029, Australia. Electronic address:
Chemotherapy-induced diarrhoea in dogs and its management with smectite: Results of a monocentric open-label randomized clinical trial.
Vet Comp Oncol
March 2021
Hospital for Small Animals, The University of Edinburgh, Royal (Dick) School of Veterinary Studies and Roslin Institute, Roslin, UK.
Chemotherapy-induced diarrhoea (CID) is a frequent chemotherapy adverse event in dogs. Yet, there is currently no consensus regarding its management. Smectite is a natural medical clay, widely used in the treatment of acute diarrhoea in humans.
View Article and Find Full Text PDFImpacts of Organomodified Nanoclays and Their Incinerated Byproducts on Bronchial Cell Monolayer Integrity.
Chem Res Toxicol
December 2019
Health Effects Laboratory Division , National Institute for Occupational Safety and Health, Morgantown , West Virginia 26505 , United States.
Incorporation of engineered nanomaterials (ENMs) into nanocomposites using advanced manufacturing strategies is set to revolutionize diverse technologies. Of these, organomodified nanoclays (ONCs; i.e.
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