A new pentacyclic triterpenoid, 3-oxo-urs-11,13(18)-dien-28-oic acid (), along with twelve known triterpenoids, -amyrin (), 19-hydroxy--amyrin (), triptohypol E (), uvaol (), 2,3-dihydroxyurs-11-en-13,28-olide (), 3-hydroxyurs-11-en-13,28-olide (), ursolic acid (), asiatic acid (), oleanolic acid (), aegiceradienol (), obtusalin () and betulinic acid () were isolated from the leaves of L. Their structures were established from spectroscopic data and comparison with reported values. Among them, compounds , , , and were isolated from the Ericaceae family for the first time. Compounds , , , and were obtained from for the first time. Additionally, compounds , and significantly inhibited the levels of NO in LPS-stimulated RAW 264.7 cells at 3 μM.
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http://dx.doi.org/10.1080/14786419.2019.1566822 | DOI Listing |
Food Chem
January 2025
Toyo Institute of Food Technology, 23-2, Minami-Hanayashiki 4-Chome, Kawanishi City, Hyogo Prefecture 666-0026, Japan. Electronic address:
The simultaneous determination of pentacyclic triterpenoids, which are secondary metabolites in plants, is difficult because of the similarity in structure and minimal differences in polarity. In this study, we established a simple and sensitive method for the simultaneous determination of pentacyclic triterpenoids based on liquid chromatography-single-quadrupole mass spectrometry (LC-MS) using a C30 column. The established method completely separated 13 pentacyclic triterpenoids based on their different retention times.
View Article and Find Full Text PDFOleanolic acid (OA) is a pentacyclic triterpenoid molecule widely distributed throughout medicinal plants. This naturally occurring OA has attracted considerable interest due to its wide range of pharmacological characteristics, notably its cytotoxic effects on various human cancer cell lines, making it a potential candidate for extensive therapeutic uses. In vivo studies have shown that OA possesses hepatoprotective, cardioprotective, anti-inflammatory and anti-microbial properties.
View Article and Find Full Text PDFSci Rep
January 2025
Section of Botany, Department of Biology, Science Faculty, Ege University, Bornova, İzmir, Turkey.
Despite its important pharmacological bioactivities, betulinic acid is still primarily obtained through extraction from heartwood and bark or synthesized synthetically, with less than 3% efficiency. Our endemic rose species, Rosa pisiformis (Christ.) D.
View Article and Find Full Text PDFPharmaceuticals (Basel)
December 2024
Department of Biotechnology, BIODIATECH-Proplanta Research Centre for Applied Biotechnology in Diagnosis and Molecular Therapy, 400478 Cluj-Napoca, Romania.
: Pentacyclic triterpenoids are increasingly studied as anticancer agents with many advantages compared to synthetic chemotherapeutics. The aim of this study was to prepare liposomal and nanostructured lipid formulations including a standardized extract of silver birch () outer bark (TTs) and to evaluate their potential as anticancer agents in vitro, using Melanoma B16-F10 and Walker carcinoma cells. : Appropriate solvents were selected for efficient TTs extraction, and original recipes were used to obtain Pegylated liposomes and nanolipid complexes with entrapped TTs, comparative to pure standards (betulinic acid and doxorubicin) in similar conditions.
View Article and Find Full Text PDFComb Chem High Throughput Screen
January 2025
Department of Cardiology, Tianjin First Center Hospital, Tianjin, China.
Background: Maslinic acid (MA), a pentacyclic triterpenoid compound derived from leaves and fruits of Olea europaea, bears multi-pharmacological properties. Our previous studies found that MA exerted a cardioprotective effect by modulating oxidative stress, inflammation, and apoptosis during myocardial ischemia-reperfusion injury (MIRI). Nevertheless, data regarding the anti-ferroptosis effects of MA on MI/RI remains unidentified.
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