A new pentacyclic triterpenoid from the leaves of L. with inhibition of NO production in LPS-induced RAW 264.7 cells.

Nat Prod Res

Key Laboratory of Natural Resources of Changbai Mountain and Functional Molecules Ministry of Education, Yanbian University College of Pharmacy, Yanji, P. R. China.

Published: December 2020

A new pentacyclic triterpenoid, 3-oxo-urs-11,13(18)-dien-28-oic acid (), along with twelve known triterpenoids, -amyrin (), 19-hydroxy--amyrin (), triptohypol E (), uvaol (), 2,3-dihydroxyurs-11-en-13,28-olide (), 3-hydroxyurs-11-en-13,28-olide (), ursolic acid (), asiatic acid (), oleanolic acid (), aegiceradienol (), obtusalin () and betulinic acid () were isolated from the leaves of L. Their structures were established from spectroscopic data and comparison with reported values. Among them, compounds , , , and were isolated from the Ericaceae family for the first time. Compounds , , , and were obtained from for the first time. Additionally, compounds , and significantly inhibited the levels of NO in LPS-stimulated RAW 264.7 cells at 3 μM.

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http://dx.doi.org/10.1080/14786419.2019.1566822DOI Listing

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