The University of Washington Quality of Life questionnaire version 4 (UW-QoLv4), in English, is used worldwide to assess the quality of life in patients with head and neck cancer. The use of such a questionnaire in other languages requires translation and validation in that language, and our aim was to translate it into Polish (which we did) and validate it in a group of patients diagnosed with head and neck cancer who had been considered free of disease for at least six months during routine follow-up visits to the Lower Silesian Oncology Center, Wrocław. Using the Polish version of the questionnaire, 66 patients filled in the translated version of UW-QoLv4 and the European Organization for Research and Treatment of Cancer (EORTC) questionnaires, which were compared and analysed. Results showed good reliability, which was confirmed by internal consistency (Cronbach's' α=0.765-0.809). The construct validity was confirmed, with strong relations between the UW-QoLv4 and the EORTC scale (p<0.05). We conclude that the Polish version of the UW-QoLv4 questionnaire seems to have been translated well, is valid, and is valuable for the assessment of quality of life among Polish patients with cancers of the head and neck.
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http://dx.doi.org/10.1016/j.bjoms.2018.12.013 | DOI Listing |
Sci Rep
December 2024
Department of Chemistry, University of Washington, Box 351700, Seattle, Washington, 98195, USA.
Trigger valves are fundamental features in capillary-driven microfluidic systems that stop fluid at an abrupt geometric expansion and release fluid when there is flow in an orthogonal channel connected to the valve. The concept was originally demonstrated in closed-channel capillary circuits. We show here that trigger valves can be successfully implemented in open channels.
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December 2024
Division of Computational & Data Sciences, Washington University in St. Louis, St. Louis, MO, USA.
Context shapes how we perceive choices and, therefore, how we decide between them. For instance, a large body of literature on the "framing effect" demonstrates that people become more risk-seeking when choices are framed in terms of losses. Despite this research, it remains unknown how people make choices between contexts and how these choices affect subsequent decision making.
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December 2024
Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
E-cigarette/vaping-associated lung injury (EVALI) is strongly associated with vitamin E acetate and often occurs with concomitant tetrahydrocannabinol (THC) use. To uncover pathways associated with EVALI, we examined cytokines, transcriptomic signatures, and lipidomic profiles in bronchoalveolar lavage fluid (BALF) from THC-EVALI patients. At a single center, we prospectively enrolled mechanically ventilated patients with EVALI from THC-containing products (N = 4) and patients with non-vaping acute lung injury and airway controls (N = 5).
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December 2024
Earth Commons, Georgetown University, Washington, DC, USA.
Observationally-derived emissions of ozone depleting substances must be scrutinized to maintain the progress made by the Montreal Protocol in protecting the stratospheric ozone layer. Recent observations of three chlorofluorocarbons (CFCs), CFC-113, CFC-114, and CFC-115, suggest that emissions of these compounds have not decreased as expected given global reporting of their production. These emissions have been associated with hydrofluorocarbon (HFC) production, which can require CFCs as feedstocks or generate CFCs as by-products, yet emissions from these pathways have not been rigorously quantified.
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December 2024
Department of Biomedicine, Aarhus University, 8000, Aarhus C, Denmark.
CD163, a macrophage-specific receptor, plays a critical role in scavenging hemoglobin released during hemolysis, protecting against oxidative effects of heme iron. In the bloodstream, hemoglobin is bound by haptoglobin, leading to its immediate endocytosis by CD163. While haptoglobin's structure and function are well understood, CD163's structure and its interaction with the haptoglobin-hemoglobin complex have remained elusive.
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