Objective: The autophagy pathway is a critical process in infection, and can be regulated by uncoordinated 51-like kinase 1 (ULK1). We investigated the associations between single-nucleotide polymorphisms (SNPs) in and risk of tuberculosis (TB) in a Chinese Han population.
Design: We recruited 380 pulmonary tuberculosis (PTB) cases, 242 extra-pulmonary tuberculosis (EPTB) cases and 606 healthy controls from a Chinese Han population and sequenced . Five SNPs in were selected to investigate the correlations between polymorphisms and TB susceptibility.
Results: The 7138581 C allele was associated with a reduced risk of PTB ( = 0.001), whereas the 9481 A allele was associated with an increased risk ( = 0.025). The 7138581 CG genotype was significantly associated with a low risk of PTB, with a higher PTB disease severity in clinical parameters. Estimation of haplotype frequencies in revealed a protective haplotype CCGAA ( = 0.007) and a potential risk haplotype TGAAA ( = 0.010) for PTB.
Conclusion: These results demonstrated that polymorphisms have significant associations with susceptibility to PTB.
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