OEGylation is an attractive approach to modifying poly(amino acid)s. OEG conjugation improves water-solubility of poly(amino acid)s, and confers possible thermal-responsive functionality for the conjugated poly(amino acid)s. Nevertheless, the impact of OEG architecture and the manner in which the OEG moiety interferes with the performances of poly(amino acid)s remain a work in progress. In this study, a series of new linear and Y-shaped OEG-substituted poly(glutamic acid)s were designed and synthesized. It is found that the thermoresponsive behavior of OEGylated poly(glutamic acid)s experiences steric repulsion effect, the strengths of which are architecture and length-dependent, and grows pronounced only when the number of the OEG units is ≥6. Notably, the Y-shaped architecture is able to stabilize the helicity of poly(glutamic acid) backbones, while maintaining higher α-helical conformation than its linear counterparts. In sum, our result indicate that Y-shaped architecture is more appropriate toward OEGylating poly(amino acid)s for biomedical applications.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1021/acs.biomac.9b00026 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Thioether functionalized degradable poly(amino acids) and its calcium sulfate/calcium hydrogen phosphate composites: Reducing oxidative stress and promoting osteogenesis.
Colloids Surf B Biointerfaces
December 2024
College of Physical, Sichuan University, Chengdu, Sichuan 610065, PR China. Electronic address:
The imbalance of redox homeostasis, especially the abnormal levels of reactive oxygen species (ROS), is a key obstacle in the bone repair process. Therefore, developing materials capable of scavenging ROS and modulating the microenvironment of bone defects is crucial for promoting bone repair. In this study, to endow poly(amino acids) (PAA) and its composites with anti-oxidative stress properties and enhanced osteogenic differentiation, we designed and prepared a calcium sulfate/calcium hydrogen phosphate/poly(amino acids) (PCDM) composite material with a thioether structure (-S-) in the molecular chain of PAA matrix through situ polymerization and physical blending method.
View Article and Find Full Text PDFRecent advances in poly(amino acids), polypeptides, and their derivatives in drug delivery.
Nanoscale
January 2025
State Key Laboratory of Physical Chemistry of Solid Surfaces, College of Chemistry and Chemical Engineering, Innovation Laboratory for Sciences and Technologies of Energy Materials of Fujian Province (IKKEM), Xiamen 361005, China.
Poly(amino acids), polypeptides, and their derivatives have demonstrated significant potential as biodegradable biomaterials in the field of drug delivery. As degradable drug carriers, they can effectively load or conjugate drug molecules including small molecule drugs, nucleic acids, peptides, and protein-based drugs, enhancing the stability and targeting of the drugs . This strategy ultimately facilitates precise drug delivery and controlled release, thereby improving therapeutic efficacy and reducing side effects within the body.
View Article and Find Full Text PDFMicroscale droplet assembly enables biocompatible multifunctional modular iontronics.
Science
November 2024
Department of Chemistry, University of Oxford, Oxford, UK.
Hydrogel iontronic devices can emulate biological functions and communicate with living matter. But the fabrication of miniature, soft iontronic devices according to modular designs has not been achieved. In this work, we report the use of surfactant-supported assembly of freestanding microscale hydrogel droplets to construct various iontronic modules, circuits, and biointerfaces.
View Article and Find Full Text PDFBioinspired peptide/polyamino acid assemblies as quorum sensing inhibitors for the treatment of bacterial infections.
J Mater Chem B
November 2024
School of Materials Science and Engineering, Tongji University, Shanghai 201804, China.
Insufficient development of new antibiotics and the rise in antimicrobial resistance are putting the world at risk of losing curative medicines against bacterial infection. Quorum sensing is a type of cellular signaling for cell-to-cell communication that plays critical roles in biofilm formation and antimicrobial resistance, and is expected to be a new type of effective target for drug resistant bacteria. In this review we highlight recent advances in bioinspired peptide/polyamino acid assemblies as quorum sensing inhibitors across various microbial communities.
View Article and Find Full Text PDFChallenges and opportunities of poly(amino acid) nanomedicines in cancer therapy.
Nanomedicine (Lond)
October 2024
Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, 5625 Renmin Street, Changchun, 130022, P. R. China.
Article Synopsis
- *Many of these nanomedicines perform better in animal studies than in actual therapeutic outcomes, raising concerns about their efficacy.
- *The review discusses the challenges in the field, such as issues with the enhanced permeability and retention effect, production methods, and highlights new opportunities from advancements in artificial intelligence.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!