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Scoping review of drug dosing recommendations in sustained low-efficiency dialysis.
Pharmacotherapy
December 2024
Department of Pharmacy, Atrium Health Carolinas Medical Center, Charlotte, North Carolina, USA.
The objective of this scoping review was to answer the question, "What has been published describing drug dosing in sustained low-efficiency dialysis (SLED)?" PubMed, Embase, and Scopus were searched on November 18, 2022. Methodology followed the Arksey and O'Malley framework for scoping reviews and Preferred Reporting Items for Systematic Reviews and Meta-Analysis Extension for Scoping Reviews guidelines. Two investigators independently screened abstracts and full-texts of citations identified related to drug dosing and SLED.
View Article and Find Full Text PDFGut microbiota regulates oxidative stress and inflammation: a double-edged sword in renal fibrosis.
Cell Mol Life Sci
December 2024
School of Pharmaceutical Sciences, Zhejiang Chinese Medical University, No. 548 Binwen Road, Hangzhou, 310053, Zhejiang, China.
Gut microbiota is a complex and dynamic system that plays critical roles in human health and various disease. Progressive chronic kidney disease (CKD) suggests that patients irreversibly progress to end-stage kidney disease and need renal replacement treatments, including dialysis and transplantation. Ample evidence indicates that local oxidative stress and inflammation play pivotal roles in the pathogenesis and progression of CKD and dysbiosis of gut microbiota.
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- Hemodialysis patients often experience left ventricular hypertrophy (LVH), and this study investigates the link between the increased uremic toxin indole-3-acetic acid (IAA) and LVH.
- 205 hemodialysis patients were analyzed, with findings indicating that those with LVH had higher IAA and phosphate levels, as well as lower hemoglobin levels.
- Results show that elevated IAA levels are positively associated with LVH, indicating that IAA might be a new biomarker for predicting LVH risk in these patients.
Determination of inorganic cations in dry milk samples deposited on a microdialysis probe by capillary electrophoresis.
Food Chem
February 2025
Department of Hygiene, Third Faculty of Medicine, Charles University, Ruská 87, 100 00, Prague 10, Czechia. Electronic address:
A tubular microdialysis probe is made from polysulfone hollow fibre for human haemodialysis, which has an inner diameter of 200 μm and a thickness of 20 μm. Milk is deposited to the outer surface of the hollow fibre and allowed to dry to form a dry sample. The tubular probe is then connected to the syringe pump and microdialysis of the dry sample into 0.
View Article and Find Full Text PDFComparative Effects of Acetate- and Citrate-Based Dialysates on Dialysis Dose and Protein-Bound Uremic Toxins in Hemodiafiltration Patients: Exploring the Impact of Calcium and Magnesium Concentrations.
Toxins (Basel)
October 2024
Nephrology and Renal Transplantation, Hospital Clínic de Barcelona, 08036 Barcelona, Spain.
Article Synopsis
- Modern hemodialysis typically uses acetate as a buffer, which has been associated with chronic inflammation, while citrate is being explored as a potential alternative for dialysate.
- This study compares the efficacy of acetate- and citrate-based dialysates in terms of dialysis efficiency and the removal of protein-bound uremic toxins in patients undergoing hemodiafiltration.
- Results showed no significant differences in overall dialysis doses or most toxin reduction, but lower calcium and magnesium citrate dialysates led to better clearance of p-cresyl sulfate, indicating a need for further research to optimize dialysate formulas.
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