Unlabelled: This study aimed to identify risk factors for failure of conservative treatment of acute OVCFs. The results showed age, BMD, BMI, mFI, and IVC were high-risk factors for failure of conservative treatment of acute OVCFs.
Purpose: This study aimed to identify risk factors for failure of conservative treatment of acute osteoporotic vertebral compression fractures (OVCFs).
Methods: This is a retrospective study of patients presenting with acute OVCFs who were initiated on conservative treatment for 3 weeks. Conservative treatment was considered to have failed if patients were not satisfied with pain relief or there were bed rest-related complications. These patients progressed to operation. Patients were divided into a conservative treatment failure group (group A) and a conservative treatment group (group B). X-ray, computed tomography and magnetic resonance imaging of two groups were performed on the first visit to our department due to OVCFs. Recorded data for comparison among groups included age, gender, fracture level, bone mineral density (BMD), body mass index (BMI), modified frailty index (mFI), whether the fractures were multiple (≥ 2 vertebral bodies was defined as multiple vertebral fractures) or combined with old fractures, and whether intervertebral cleft (IVC) was present.
Results: We collected data from 173 patients who underwent conservative treatment of acute OVCF in our hospital. Of these, 71 had conservative treatment failure, while 102 patients succeeded in long-term conservative treatment. After logistic regression analysis, age, BMD, BMI, mFI, and IVC were identified as high-risk factors for conservative treatment failure (P < 0.05). Age, BMD, BMI, and mFI were included in receiver operating characteristic curve analysis, the result showed that the cutoff value of age was 73.5 years old, of BMI was 23.65 kg/m, of BMD was - 3.45, and mFI was 2.5.
Conclusion: According to the results of this study, patients with high-risk factors should be actively observed during conservative treatment, especially for patients with all of the above risk factors, but further research would be required before considering early-stage treatment policy change.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1007/s11657-019-0563-8 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Endoscopic injection sclerotherapy (EIS) is a useful prophylactic hemostatic procedure for esophageal varices. However, injecting sclerosing agents into blood vessels is technically challenging and often ineffective. Gel-immersion EIS (GI-EIS) may facilitate easier intravascular sclerosing agent injection by dilating the varices and enhancing scope stability by maintaining low intra-gastrointestinal pressure.
View Article and Find Full Text PDFMolecular analysis of HPV16 and HPV18 oncogenes in oral squamous cell carcinoma: Structural, transcriptomic and insights.
Oncol Lett
March 2025
Department of Conservative Dentistry and Endodontics, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, Tamil Nadu 600077, India.
The present study investigated the involvement of human papillomavirus (HPV)16 and HPV18 in oropharyngeal malignancies in order to understand the oncogenic mechanisms, and to identify biomarkers for early detection and treatment targets. Given the rising incidence of HPV-associated cancer, particularly in India, this holds significance in elucidating the molecular basis of these diseases. Structural validation of HPV16 and 18 oncoproteins E6 and E7 was conducted using computational tools, while gene expression profiles related to oral squamous cell carcinoma (OSCC) were analyzed to assess differential expression.
View Article and Find Full Text PDFClinical and radiological comparisons of isolated posterior malleolar fractures treated surgically and conservatively.
Eur J Trauma Emerg Surg
January 2025
Department of Orthopedics and Traumatology, Etlik City Hospital, Ankara, Turkey.
Background: Isolated posterior malleolar (PM) fractures are rare fractures without consensus regarding treatment decisions and functional outcomes. The study aims to compare the clinical and radiological results of patients treated surgically or conservatively for isolated PM fractures.
Methods: The study included 30 patients who presented with an isolated PM fracture and were treated conservatively (n = 15) or with surgery (n = 15).
The effect of mandibular advancement on pharyngeal airway space in patients with oral squamous cell carcinoma: A monocentric prospective study with computed tomography.
Clin Oral Investig
January 2025
Department of Oral and Maxillofacial Surgery, Klinikum Rechts Der Isar, School of Medicine and Health, Technische Universität München, Ismaninger Str. 22, Munich, D-81679, Germany.
Objectives: The presented study aimed to evaluate the effect of mandibular protrusion with a temporarily applied mandibular advancement device (MAD) on the posterior airway space and to determine a reliable metric constant based on a three-dimensional computed tomography (CT) evaluation.
Materials And Methods: The study population consisted of patients with oral squamous cell carcinoma who were treated at least six months prior to the follow-up CT in supine position. Each patient received an individually adjusted MAD that was temporarily applied with three different protrusion distances (P = 0 mm, P = 4 mm, and P = 8 mm) during follow-up CT.
Early muscular training and immobilization in external rotation could reduce the recurrence rate in first-time shoulder dislocators among young rugby athletes.
J Shoulder Elbow Surg
January 2025
Department of Orthopaedic Surgery, Osaka International Medical & Science Center, Osaka, Japan; Center for Sports Medicine, Osaka International Medical & Science Center, Osaka, Japan. Electronic address:
Background: Among rugby players, anterior shoulder dislocation is challenging to treat during the in-season period. It often leads to recurrent shoulder instability and requires prolonged rest post-surgery. No studies have determined the effectiveness of immobilization, early muscle strength training, or both in preventing reinjury in this population.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!