Over 20 million Americans have abused inhalants at least once in their lifetime. It is widely known that "huffing" increases risk for liver disease, renal failure, hypoxia, respiratory failure, dysrhythmias, and cardiac arrest. However, it is lesser known that inhalants can also cause thermal or frostbite injury. This study is a review of 2003 to 2012 National Burn Repository (NBR) records with a query for "huff," "inhalant," and corresponding ICD-9 codes. The NBR represents the cumulative data of subjects presenting to regional burn centers throughout the nation. Twenty-eight cases of inhalant injury were found. Approximately one-third were due to frostbite secondary to cold liquids exiting aerosol cans. The remaining two-third were due to thermal injury when the flammable solvent ignited. Median burn size was 3% total BSA (TBSA). Eight patients suffered inhalation injuries and one patient died. Although the median burn size of these patients was relatively small, some had significant injuries requiring long hospital length of stay. Direct costs of healthcare and indirect costs of lost wages make inhalant injury a significant public health problem. Multidisciplinary governmental efforts should be focused on prevention, education, recognition, and early intervention when inhalant abuse is suspected.
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http://dx.doi.org/10.1093/jbcr/irz025 | DOI Listing |
Clin Toxicol (Phila)
January 2025
Family Physician in Private Practice, Singapore.
Introduction: Ethyl chloride misuse remains a prevailing concern due to its accessibility, but detailed descriptions of the features of toxicity are limited to sporadic reports, resulting in knowledge gaps in their clinical features and diagnosis.
Objective: To describe the clinical features, treatment, and outcomes of patients reported in the literature who developed toxicity from inhalational use of ethyl chloride.
Methods: We reviewed relevant literature over the past 50 years and analyzed the characteristics and outcomes of patients with toxicity from the inhalational use of ethyl chloride.
Clin Cardiol
November 2024
Department of Internal Medicine, Istanbul University, Faculty of Medicine, Istanbul, Turkey.
Background: Volatile substance (thinner) addiction can cause serious cardiac events, such as malignant ventricular arrhythmias, acute coronary syndromes, sudden death syndrome, and dilated cardiomyopathy, as reported in many case studies. We aimed to find echocardiographic and electrocardiographic parameters that could foresee these adverse outcomes in clinical settings.
Methods: We enrolled 32 healthy young adult patients with at least 1 year of thinner addiction and no cardiac symptoms.
Cureus
August 2024
Critical Care Medicine, Ascension Providence Hospital, Southfield, USA.
PLoS One
September 2024
Instituto de Ciencias Aplicadas y Tecnología, Universidad Nacional Autónoma de México, Mexico City, Mexico.
Analyzing functional brain activity through functional magnetic resonance imaging (fMRI) is commonly done using tools from graph theory for the analysis of the correlation matrices. A drawback of these methods is that the networks must be restricted to values of the weights of the edges within certain thresholds and there is no consensus about the best choice of such thresholds. Topological data analysis (TDA) is a recently-developed tool in algebraic topology which allows us to analyze networks through combinatorial spaces obtained from them, with the advantage that all the possible thresholds can be considered at once.
View Article and Find Full Text PDFForensic Sci Int
July 2024
Department of Forensic Toxicology, Academy of Forensic Science, Shanghai Key Laboratory of Forensic Medicine, Shanghai Forensic Science Platform, Key Laboratory of Forensic Sciences, Ministry of Justice, Shanghai 200063, PR China. Electronic address:
Nitrous oxide (NO), also known as laughing gas, has a euphoric effect and is becoming increasingly popular as a recreational inhalant drug. Deaths caused by recreational nitrous oxide abuse are rare, but may still occur. Although some methods for the quantification of NO by GC-MS have been reported, elimination of carbon dioxide interference and the choice of a suitable internal standard remain current limitations to accurate NO quantification.
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