Long noncoding RNA (lncRNA) mortal obligate RNA transcript (MORT) was downregulated many types of cancer tissues, while its functionality in cancer biology is unclear. In the present study, we systemically investigated the involvement of lncRNA MORT in oral squamous cell carcinoma (OSCC). In the present study, we found that lncRNA MORT was downregulated, while rho-associated coiled-coil containing protein kinase 1 (ROCK1) messenger RNA was upregulated in cancer tissues than in adjacent healthy tissues of OSCC patients. In addition, expression levels of lncRNA MORT and ROCK1 were inversely correlated in both tumor tissues and healthy tissues. Follow-up study showed that low MORT level was significantly correlated with poor survival. Overexpression of lncRNA MORT inhibited the proliferation of OSCC cells and downregulated ROCK1. ROCK1 overexpression led to significantly promoted cell proliferation but showed no significant effect on MORT expression. In addition, ROCK1 overexpression attenuated the inhibitory effects of lncRNA MORT overexpression on the proliferation of OSCC cells. Therefore, lncRNA MORT overexpression may inhibit cancer cell proliferation in OSCC cells by downregulating ROCK1.
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http://dx.doi.org/10.1002/jcb.28449 | DOI Listing |
Am J Physiol Cell Physiol
December 2024
Department of Orbital Disease and Ocular Plastic Surgery, The Second Hospital of Jilin University, Changchun, People's Republic of China.
This study investigates the role of the long noncoding RNA (lncRNA) in uveal melanoma (UM), focusing on its function within a competing endogenous RNA (ceRNA) network. Using the UM-related TCGA (The Cancer Genome Atlas) dataset, we analyzed the expression levels of and its correlation with and , an essential autophagy-related gene. Our analysis revealed that acts as a ceRNA by competitively binding to , resulting in the upregulation of .
View Article and Find Full Text PDFNucleosides Nucleotides Nucleic Acids
January 2025
Department of Genetics, Molecular Cell Group, Faculty of Basic Science, Islamic Azad University of Ahar, Ahar, Iran.
Aberrant DNA methylation plays essential roles in the colorectal cancer (CRC) carcinogenesis and has been demonstrated as a promising marker for cancer early detection. In this project, methylation status of the promoter was studied in CRC and their marginal tissues using qMSP assay. Furthermore, we investigated the molecular function of in CRC progression using computational analysis.
View Article and Find Full Text PDFEur Rev Med Pharmacol Sci
October 2021
Department of Oncology Radiotherapy, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, Hunan, China.
Objective: To explore the biological function of long non-coding RNA (lncRNA) MORT in the malignant progression of breast cancer (BCa) and the underlying mechanism, and to provide a novel strategy for clinical treatment.
Patients And Methods: Quantitative Real Time-Polymerase Chain Reaction (qRT-PCR) was conducted to detect differential level of MORT in BCa specimens and cell lines. The correlation between MORT level and pathological indexes of BCa patients was analyzed.
Autoimmunity
November 2021
Department of Rheumatism Immunology, Hubei Provincial Hospital of Traditional Chinese Medicine, Wuhan, China.
Background: Rheumatoid arthritis (RA) is an autoimmune disease, which compromises the synovial membrane resulting in chronic inflammation. Increasing evidence has demonstrated that long non-coding RNAs (lncRNAs) are implicated in the pathogenesis of RA. This study investigated the role of lncRNA ZNF667-AS1 in RA progression.
View Article and Find Full Text PDFInt J Mol Sci
July 2021
Department of Anatomy, Faculty of Medicine and Surgery, University of Malta, MSD 2080 Msida, Malta.
Gynecological cancers (GCs) are currently among the major threats to female health. Moreover, there are different histologic subtypes of these cancers, which are defined as 'rare' due to an annual incidence of <6 per 100,000 women. The majority of these tend to be associated with a poor prognosis.
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