AI Article Synopsis
- The M-CRIB atlas includes 100 neonatal brain regions, with 68 aligned to the Desikan-Killiany adult cortical atlas and aims to improve accuracy and labeling based on clearer anatomical landmarks.
- Updates to cortical and subcortical regions were made by editing MRI scans from 10 healthy neonates, resulting in the M-CRIB 2.0 atlas featuring 94 regions.
- This atlas ensures better compatibility with adult data and can be easily integrated into neonatal research pipelines, enabling studies on brain structure and function from infancy through adulthood.
Article Abstract
Our recently published M-CRIB atlas comprises 100 neonatal brain regions including 68 compatible with the widely-used Desikan-Killiany adult cortical atlas. A successor to the Desikan-Killiany atlas is the Desikan-Killiany-Tourville atlas, in which some regions with unclear boundaries were removed, and many existing boundaries were revised to conform to clearer landmarks in sulcal fundi. Our first aim here was to modify cortical M-CRIB regions to comply with the Desikan-Killiany-Tourville protocol, in order to offer: (a) compatibility with this adult cortical atlas, (b) greater labeling accuracy due to clearer landmarks, and (c) optimisation of cortical regions for integration with surface-based infant parcellation pipelines. Secondly, we aimed to update subcortical regions in order to offer greater compatibility with subcortical segmentations produced in FreeSurfer. Data utilized were the T2-weighted MRI scans in our M-CRIB atlas, for 10 healthy neonates (post-menstrual age at MRI 40-43 weeks, four female), and corresponding parcellated images. Edits were performed on the parcellated images in volume space using ITK-SNAP. Cortical updates included deletion of frontal and temporal poles and 'Banks STS,' and modification of boundaries of many other regions. Changes to subcortical regions included the addition of 'ventral diencephalon,' and deletion of 'subcortical matter' labels. A detailed updated parcellation protocol was produced. The resulting whole-brain M-CRIB 2.0 atlas comprises 94 regions altogether. This atlas provides comparability with adult Desikan-Killiany-Tourville-labeled cortical data and FreeSurfer-labeed subcortical data, and is more readily adaptable for incorporation into surface-based neonatal parcellation pipelines. As such, it offers the ability to help facilitate a broad range of investigations into brain structure and function both at the neonatal time point and developmentally across the lifespan.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6371012 | PMC |
| http://dx.doi.org/10.3389/fnins.2019.00034 | DOI Listing |
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Article Synopsis
- The M-CRIB atlas includes 100 neonatal brain regions, with 68 aligned to the Desikan-Killiany adult cortical atlas and aims to improve accuracy and labeling based on clearer anatomical landmarks.
- Updates to cortical and subcortical regions were made by editing MRI scans from 10 healthy neonates, resulting in the M-CRIB 2.0 atlas featuring 94 regions.
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January 2019
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