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Transcriptome-guided breeding for Paspalum notatum: producing apomictic hybrids with enhanced omega-3 content.
Theor Appl Genet
December 2024
Instituto de Investigaciones en Ciencias Agrarias de Rosario (IICAR-CONICET-UNR), Parque Villarino S/N, Z2125ZAA Zavalla, Rosario, Santa Fe, Argentina.
Transcriptomics- and FAME-GC-MS-assisted apomixis breeding generated Paspalum notatum hybrids with clonal reproduction and increased α-linolenic acid content, offering the potential to enhance livestock product's nutritional quality and reduce methane emissions A low omega-6:omega-3 fatty acid ratio is considered an indicator of the nutritional impact of milk fat on human health. In ruminants, major long-chain fatty acids, such as linoleic acid (18:2, omega-6) and α-linolenic acid (18:3, omega-3), originate from dietary sources and reach the milk via the bloodstream. Since forages are the primary source of long-chain fatty acids for such animals, they are potential targets for improving milk lipid composition.
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Aktuelle Urol
December 2024
Allgemeine und geriatrische Rehabilitation, Klinik Wartenberg, Wartenberg, Germany.
Tlr7 drives sex- and tissue-dependent effects in Sjögren's disease.
Front Cell Dev Biol
September 2024
Department of Oral Biology, School of Dental Medicine, The University at Buffalo, State University of New York, Buffalo, NY, United States.
Article Synopsis
- Primary Sjögren's disease (pSD) is an autoimmune disorder predominantly affecting females, but the reasons for this gender difference are not well understood.
- In a study using a pSD mouse model, it was found that female mice exhibited reduced eye gland inflammation but increased kidney inflammation compared to male mice, with notable differences in immune cell populations and antibody levels.
- The research identified Tlr7 as a key factor influencing gender-specific disease manifestations, suggesting it may be a potential target for treatment and emphasizing the need to study both sexes in autoimmune disease research.
Safety and efficacy of topical testosterone in breast cancer patients receiving ovarian suppression and aromatase inhibitor therapy.
Breast Cancer Res
September 2024
Centro de Oncologia e Hematologia Einstein Dayan-Daycoval, Hospital Israelita Albert Einstein, Sao Paulo, Brazil.
Background: Premenopausal, high-risk, hormone receptor-positive breast cancer patients are often treated with ovarian suppression in combination with aromatase inhibitors (AI). This combination has important adverse effects, particularly in sexual function, such as vaginal dryness and loss of libido. There is no effective therapy for reduced sexual function in this setting.
View Article and Find Full Text PDFLoss-of-Function Variant in PPP1R12A -Related Urogenital and/or Brain Malformation Syndrome: Expanded Phenotype of Sex Reversal.
Am J Med Genet A
January 2025
Hospital Regional de Alta Especialidad de la Península de Yucatán, Mérida, Yucatán, Mexico.
Differences of sex development (DSDs) are a heterogeneous group of congenital conditions in which chromosomal, gonadal, or anatomical sex does not match. The broad spectrum of phenotypes associated with DSDs requires accurate diagnosis, which influences the care and quality of life of affected patients. The decreasing costs of next-generation sequencing (NGS) and international research collaborations in rare diseases have allowed the identification of new genes associated with DSDs.
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