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| http://dx.doi.org/10.1164/rccm.201901-0233ED | DOI Listing |
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From setbacks to success: lessons from the journey of RSV vaccine development.
Ther Adv Vaccines Immunother
December 2024
Centre for Human Drug Research, Leiden, The Netherlands.
Respiratory syncytial virus (RSV) causes high worldwide infant mortality, as well as a high disease burden in the elderly. Efforts in vaccine development over the past 60 years have recently delivered three approved vaccines and two monoclonal antibodies (mAbs). Looking back at the eventful history of RSV vaccine development, several factors can be identified that have hampered the developmental pathway, including the occurrence of enhanced RSV disease (ERD) in the first vaccine attempt and the difficulty in characterizing and stabilizing the pre-fusion F protein as a vaccine target.
View Article and Find Full Text PDFFail-Fast in Respiratory Syncytial Virus Vaccine Development.
Am J Respir Crit Care Med
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1Wilhelmina's Children's HospitalUniversity Medical Center UtrechtUtrecht, the Netherlands.
Does minimally invasive thoracic surgery warrant fast tracking of thoracic surgical patients?
Thorac Surg Clin
August 2008
Division of Cardiothoracic Surgery, Department of Surgery, University of Alabama at Birmingham, 703 19th Street S, ZRB 739, Birmingham, AL 35294, USA.
Fast-tracking protocols or postoperative care computerized algorithms have been shown to reduce hospital LOS and reduce costs for patients. who undergo both open and VATS procedures The ability to fast-track is not governed by the type of procedure (closed versus open), but rather by patient characteristics and the mindset of the operating surgeon and the postoperative care team. While use of protocols enhance the ability of many physicians to fast-track many different types of patients, it is a mistake to force these protocols on all patients because, if not modified, they can lead to increased complications, readmissions, and low patient and family satisfaction.
View Article and Find Full Text PDFThe influence of preoperative risk stratification on fast-tracking patients after pulmonary resection.
Thorac Surg Clin
February 2008
Division of Cardiothoracic Surgery, Department of Surgery, University of Alabama at Birmingham, 703 19th Street S, ZRB 739, Birmingham, AL 35294, USA.
Fast-tracking protocols or postoperative care computerized algorithms have been shown to reduce hospital length of stay and reduce costs; however, not all patients can be fast-tracked. Certain patient characteristics may put patients at increased risk to fail fast-tracking. Additionally some patients have multiple risk factors that have an additive effect that puts them at an even increased risk to fail fast-tracking, and more importantly, to significant morbidity.
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