Since the online publication of the above article, the authors have noted an error with the name of the co-author Dr Liang (Last name) Hong (first name).
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6662242 | PMC |
| http://dx.doi.org/10.1038/s41433-019-0373-7 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
A statistical framework for analysis of trial-level temporal dynamics in fiber photometry experiments.
Elife
March 2025
Machine Learning Core, National Institute of Mental Health, Bethesda, United States.
Fiber photometry has become a popular technique to measure neural activity in vivo, but common analysis strategies can reduce the detection of effects because they condense signals into summary measures, and discard trial-level information by averaging . We propose a novel photometry statistical framework based on functional linear mixed modeling, which enables hypothesis testing of variable effects at , and uses trial-level signals without averaging. This makes it possible to compare the timing and magnitude of signals across conditions while accounting for between-animal differences.
View Article and Find Full Text PDFAsymmetry of centrosomes in neural stem cells requires protein phosphatase 4.
Mol Biol Cell
March 2025
Department of Biology, University of Washington, Life Sciences Building, Seattle, WA 98105, USA.
Asymmetric cell division is used by stem cells to create diverse cell types while self-renewing the stem cell population. Biased segregation of molecularly distinct centrosomes could provide a mechanism to maintain stem cell fate, induce cell differentiation or both. However, the molecular mechanisms generating molecular and functional asymmetric centrosomes remain incompletely understood.
View Article and Find Full Text PDFPorous Silicon Nanoneedles Efficiently Deliver Adenine Base Editor to Correct a Recurrent Pathogenic COL7A1 Variant in Recessive Dystrophic Epidermolysis Bullosa.
Adv Mater
March 2025
Centre for Craniofacial and Regenerative Biology, King's College London, London, SE1 1UL, UK.
Base editing, a CRISPR-based genome editing technology, enables precise correction of single-nucleotide variants, promising resolutive treatment for monogenic genetic disorders like recessive dystrophic epidermolysis bullosa (RDEB). However, the application of base editors in cell manufacturing is hindered by inconsistent efficiency and high costs, contributed by suboptimal delivery methods. Nanoneedles have emerged as an effective delivery approach, enabling highly efficient, non-perturbing gene therapies both in vitro and in vivo.
View Article and Find Full Text PDFSpectroscopic Study of Methylene Blue Interaction with Coenzymes and its Effect on Tumor Metabolism.
Sovrem Tekhnologii Med
March 2025
Junior Researcher, Laser Biospectroscopy Laboratory, Light-Induced Surface Phenomena Department, Natural Sciences Center; Prokhorov General Physics Institute of the Russian Academy of Sciences, 38 Vavilov St., Moscow, 119991, Russia.
Unlabelled: is to study the interaction of methylene blue (MB) with NADH, FADH coenzymes and lactate, and to evaluate a long-term effect of its intravenous or oral introduction on tumor metabolism .
Materials And Methods: The MB interaction with NADH, FADH coenzymes and lactate was studied using absorption spectrophotometry. A long-term effect of MB on tumor metabolism was investigated on a mice model of Ehrlich carcinoma.
Haplotype-based association between paternal DNMT1 variants and nonsyndromic cleft lip or without cleft palate in Chile.
J World Fed Orthod
March 2025
Institute for Research in Dental Sciences, School of Dentistry, Universidad de Chile, Santiago, Chile. Electronic address:
Background: DNA methyltransferase 1 (DNMT1) is responsible for epigenetic remodeling of the genome during spermatogenesis and maintenance of DNA methylation. The current study aimed to assess the possible association between paternal polymorphic variants of the gene encoding DNMT1 enzyme and the risk of nonsyndromic cleft lip with or without cleft palate (NSCL/P) expression in offspring.
Methods: Nine DNMT1 polymorphic single nucleotide polymorphism (SNP) variants were analyzed in 101 fathers of NSCL/P Chilean cases and 187 fathers of controls.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!