AI Article Synopsis
- A new enzymatic protocol utilizes lipase to create (E)-α,β-unsaturated carboxylic esters through a cascade of organic reactions starting from acetals and cyanoacetic acid.
- The method leverages the versatile nature of enzymes, allowing for the synthesis of complex molecules in a single reaction step.
- Key findings include the impact of enzyme type, solvent, and temperature on the reaction, along with benefits like simplified processing, high selectivity of products, and the ability to recycle the biocatalyst.
Article Abstract
A new enzymatic protocol based on lipase-catalyzed cascade toward (E)-α,β-unsaturated carboxylic esters is presented. The proposed methodology consists of elementary organic processes starting from acetals and cyanoacetic acid leading to the formation of desired products in a cascade sequence. The combination of enzyme promiscuous abilities gives a new opportunity to synthesize complex molecules in the one-pot procedure. Results of studies on the influence of an enzyme type, solvent, and temperature on the cascade reaction course are reported. The presented methodology provides meaningful qualities such as significantly simplified process, excellent E-selectivity of obtained products and recycling of a biocatalyst.
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| http://dx.doi.org/10.1016/j.bioorg.2019.02.041 | DOI Listing |
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