The atrioventricular node (AV) is considered the electrical connection between the atria and ventricles. There is an electrical pause between activation of the atria and the ventricles (PR segment), but to date the mechanism responsible for this interruption remains unclear. The present communication focuses on the hypothesis that magnetic field dynamics could provide the answer. Proof of this hypothesis is that in Wolff-Parkinson-White syndrome, where there is physical connection between the atria and ventricles (bundle of Kent), there is electrical AV continuity, no PR segment is detected, and catheter ablation of the abnormal bundle restores AV discontinuity. Spontaneous initiation of the heart at the level of the sinus node, the pacemaker of the heart, could also be explained via field dynamics. The known transmembrane pacemaker protein CHN4, present in both sinoatrial and AV nodal cells, could interact with field information to provide specificity in an electronic key-to-lock mechanism interaction.

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.mehy.2019.02.012DOI Listing

Publication Analysis

Top Keywords

field dynamics
12
atria ventricles
12
connection atria
8
field
4
dynamics atrioventricular
4
atrioventricular activation
4
activation clinical
4
clinical evidence
4
evidence specific
4
specific field-to-protein
4

Similar Publications

This study employed large eddy simulation (LES) with the wall-adapting local eddy-viscosity (WALE) model to investigate transitional flow characteristics in an idealized model of a healthy thoracic aorta. The OpenFOAM solver pimpleFoam was used to simulate blood flow as an incompressible Newtonian fluid, with the aortic walls treated as rigid boundaries. Simulations were conducted for 30 cardiac cycles and ensemble averaging was employed to ensure statistically reliable results.

View Article and Find Full Text PDF

Highly printable, strong, and ductile ordered intermetallic alloy.

Nat Commun

January 2025

Department of Materials Science and Engineering, College of Engineering, City University of Hong Kong, Hong Kong, China.

Ordered intermetallic alloys are renowned for their impressive mechanical, chemical, and physical properties, making them appealing for various fields. However, practical applications of them have long been severely hindered due to their severe brittleness and poor fabricability. It is difficult to fabricate such materials into components with complex geometries through traditional subtractive manufacturing methods.

View Article and Find Full Text PDF

Revisiting secondary model features for describing the shoulder and lag parameters of microbial inactivation and growth models.

Int J Food Microbiol

January 2025

Departamento de Ingeniería de Alimentos y del Equipamiento Agrícola, Instituto de Biotecnología Vegetal, Universidad Politécnica de Cartagena (ETSIA), Paseo Alfonso XIII, 48, 30203 Cartagena, Spain.

The Baranyi and Geeraerd models are two of the most reliable models for the description of, respectively, microbial growth and inactivation. They are defined as a system of differential equations, whose algebraic solution can describe the microbial response during isothermal conditions, especially when combined with suitable secondary models. However, there are still large uncertainties regarding the best functions to use as secondary models for the lag phase duration (λ) and the shoulder length (S).

View Article and Find Full Text PDF

Emerging roles for tubulin PTMs in neuronal function and neurodegenerative disease.

Curr Opin Neurobiol

January 2025

Department of Pathology & Cell Biology, Columbia University Irving Medical Center, 10032, New York, NY, USA. Electronic address:

Neurons are equipped with microtubules of different stability with stable and dynamic domains often coexisting on the same microtubule. While dynamic microtubules undergo random transitions between disassembly and assembly, stable ones persist long enough to serve as platforms for tubulin-modifying enzymes (known as writers) that attach molecular components to the α- or β-tubulin subunits. The combination of these posttranslational modifications (PTMs) results in a "tubulin code," dictating the behavior of selected proteins (known as readers), some of which were shown to be crucial for neuronal function.

View Article and Find Full Text PDF

The oceanic dissolved organic matter (DOM) reservoir is one of Earth's largest carbon pools, yet the factors contributing to its recalcitrance and persistence remain poorly understood. Here, we employed ultra-high resolution mass spectrometry (UHRMS) to examine the molecular dynamics of DOM from terrestrial, marine and mixed sources during bio-incubation over weekly, monthly, and one year time spans. Using Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR MS), we classified DOM into three distinct categories (Consumed, Resistant and Product) based on their presence or absence at the start and end of the incubation.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!