AI Article Synopsis
- The novel compound 12-deoxytrichodermin was isolated from the fungus Trichoderma sp. 1212-03 for research on its effects against colon cancer cells and a specific fungus.
- The study indicated that the presence of the 12-epoxide group is vital for the effectiveness of certain trichothecenes in killing cancer cells, while it's not necessary for others.
- However, the 12-epoxide is essential for the antifungal properties of trichothecenes, emphasizing its importance in different biological activities.
Article Abstract
The novel trichothecene 12-deoxytrichodermin (3) was isolated from the fungus Trichoderma sp. 1212-03, and included with other known natural trichothecenes in a structure-activity relationship investigation against a human colon cancer cell line (COLO201) and filamentous fungus Cochliobolus miyabeanus. This revealed that the 12-epoxide functionality is critical for the cytotoxicity of simple trichothecenes trichodermin (4) and deoxynivalenol (2), while not critical for the cytotoxicity of roridin J (6) and epiisororidin E (8). In contrast, 12-epoxide is essential for the antifungal activity.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.bmcl.2019.02.015 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Functional Expression and Construction of a Self-Sufficient Cytochrome P450 Chimera for Efficient Steroidal C14α Hydroxylation in Escherichia coli.
Biotechnol Bioeng
December 2024
National and Local Joint Engineering Research Center for Biomanufacturing of Choral Chemicals, Zhejiang University of Technology, Hangzhou, People's Republic of China.
C14-functionalized steroids enabled diverse biological activities in anti-gonadotropin and anticancer therapy. However, access to C14-functionalized steroids was impeded by the deficiency of chemical synthetic methods. Recently, several membrane-bound fungal cytochrome P450s (CYPs) have been identified with steroid C14α-hydroxylation activity.
View Article and Find Full Text PDFEnhances Brown Spot Disease Resistance in Rice.
Plants (Basel)
November 2024
Department of Plant Bioscience, College of Natural Resources and Life Science, Pusan National University, Miryang 50463, Republic of Korea.
Brown spot (BS) is caused by necrotrophs fungi () which affects rainfed and upland production in rice, resulting in significant losses in yield and grain quality. Here, we explored the meJA treatment that leads to rice resistance to BS. Fibrillins (FBNs) family are constituents of plastoglobules in chloroplast response to biotic and abiotic stress, many research revealed that and are not only associated with the rice against disease but also with the JA pathway.
View Article and Find Full Text PDFAntimicrobial polyketides from an endophytic fungus HJ-7 from Hance.
Nat Prod Res
November 2024
State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources (Ministry of Education of China), Collaborative Innovation Center for Guangxi Ethnic Medicine, School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin, People's Republic of China.
Eleven polyketide derivatives, including two new compounds, xanthoradone D () and arisochromophilone (), were isolated from HJ-7, a Chinese medicinal plant Hance-associated fungus. Their structures were elucidated on the basis of spectroscopic analysis and ECD (Electronic Circular Dichroism) calculations. The antibacterial and antifungal activities of the compounds were evaluated.
View Article and Find Full Text PDFThe complete mitogenome of (Kunze) Wiltshire 1933 (Pleosporaceae), a fungus causing apple leaf blotch disease.
Mitochondrial DNA B Resour
October 2024
Yunnan Key Laboratory of Potato Biology, Yunnan Normal University, Kunming, China.
Article Synopsis
- Kunze Wiltshire 1933 is a fungus that causes leaf blotch disease in plants, and the study focused on assembling its mitochondrial genome from isolate AT-1224.
- The mitochondrial genome has a size of 57,475 bp, featuring 12 coding genes, 15 hypothetical proteins, 34 tRNA genes, and 2 rRNA genes, along with various repetitive sequences.
- Phylogenetic analysis indicated close relationships with two species and placed it in a sister clade with six other species, providing important insights for future identification and evolutionary studies related to this fungus in apple orchards.
A Nanopore-sequenced high-quality genome of the strain Bo-1.
Microbiol Resour Announc
November 2024
National Key Laboratory of Agricultural Microbiology, Hubei Hongshan Laboratory, Hubei Key Laboratory of Plant Pathology, The Center of Crop Nanobiotechnology, Huazhong Agricultural University, Wuhan, China.
Brown spot disease of rice caused by results in severe yield losses. A high-quality genome was assembled using Nanopore sequencing data, resulting in a 36-Mb nuclear genome with 19 contigs and a mitogenome. This assembly provides valuable genetic resources for investigations of rice- interactions.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!