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| http://dx.doi.org/10.1038/s41375-019-0423-y | DOI Listing |
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To maintain genome stability, proliferating cells must enact a program of telomere maintenance. While most tumors maintain telomeres through the action of telomerase, a subset of tumors utilize a DNA-templated process termed Alternative Lengthening of Telomeres or ALT. ALT is associated with mutations in the ATRX/DAXX/H3.
View Article and Find Full Text PDFMaintaining Telomeres without Telomerase in : Novel Mechanisms and Rapid Evolution to Save a Genus.
Cold Spring Harb Perspect Biol
December 2024
Department of Biology and Biotechnology, Sapienza University of Rome, 00185 Rome, Italy
Telomere maintenance is crucial for preventing the linear eukaryotic chromosome ends from being mistaken for DNA double-strand breaks, thereby avoiding chromosome fusions and the loss of genetic material. Unlike most eukaryotes that use telomerase for telomere maintenance, relies on retrotransposable elements-specifically , , and (collectively referred to as HTT)-which are regulated and precisely targeted to chromosome ends. telomere protection is mediated by a set of fast-evolving proteins, termed terminin, which bind to chromosome termini without sequence specificity, balancing DNA damage response factors to avoid erroneous repair mechanisms.
View Article and Find Full Text PDFThe Isodon serra genome sheds light on tanshinone biosynthesis and reveals the recursive karyotype evolutionary histories within Lamiales.
Plant J
January 2025
School of Pharmacy, Lanzhou University, Lanzhou, 730000, China.
Lamiales is one of the largest orders of angiosperms with a complex evolutionary history and plays a significant role in human life. However, the polyploidization and chromosome evolution histories within this group remain in mystery. Among Lamiales, Isodon serra (Maxim.
View Article and Find Full Text PDFEstablishment and characterization of the Cuvier's beaked whale (Ziphius cavirostris) myogenic cell line.
Res Vet Sci
January 2025
Department of Comparative Biomedicine and Food Science, University of Padova, Legnaro, PD, Italy.
Article Synopsis
- This study presents a novel in vitro muscle-derived cell line from a stranded male Cuvier's Beaked whale, facilitating research on its myogenic cells.
- The characterization involved various assays that assessed growth rate, fusion index, and chromosomal analysis, showing the cells' capability to fuse into multinucleated myotubes over time.
- The findings highlight the potential of this whale cell line for understanding cetacean muscle physiology and assessing the impacts of water pollutants through in vitro models.
Adaptive protein coevolution preserves telomere integrity.
bioRxiv
November 2024
Department of Biology and Epigenetics Institute, University of Pennsylvania, Philadelphia, PA.
Many essential conserved functions depend, paradoxically, on proteins that evolve rapidly under positive selection. How such adaptively evolving proteins promote biological innovation while preserving conserved, essential functions remains unclear. Here, we experimentally test the hypothesis that adaptive protein-protein coevolution within an essential multi-protein complex mitigates the deleterious incidental byproducts of innovation under pressure from selfish genetic elements.
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