A special issue of celebrates the 2018 Symposium of the Society of General Physiologists, where diversity and world-class science went hand in hand.
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| http://dx.doi.org/10.1085/jgp.201912340 | DOI Listing |
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Regulation of myocardial contraction as revealed by intracellular Ca measurements using aequorin.
J Physiol Sci
January 2025
Department of Cell Physiology, The Jikei University School of Medicine, 3-25-8 Nishi-Shimbashi, Minato-Ku, 105-8461, Tokyo, Japan.
Of the ions involved in myocardial function, Ca is the most important. Ca is crucial to the process that allows myocardium to repeatedly contract and relax in a well-organized fashion; it is the process called excitation-contraction coupling. In order, therefore, for accurate comprehension of the physiology of the heart, it is fundamentally important to understand the detailed mechanism by which the intracellular Ca concentration is regulated to elicit excitation-contraction coupling.
View Article and Find Full Text PDFDiscovery that cells have plasma membrane portals called porosomes that govern secretion.
Discoveries (Craiova)
October 2023
Professor of Translational Cardiology, University of Southern Denmark, Odense, Denmark.
A large number of products are synthesized and packaged in membrane vesicles to be secreted from cells to carry out essential physiological functions such as nerve transmission, digestion and immune response. How do cells secrete with great precision a portion of the vesicle contents?These questions have been answered through the work of Dr. Bhanu P.
View Article and Find Full Text PDFThe patterns in urine excretion and transvascular fluid exchange in human subjects during intravenous fluid infusion: A quantitative analysis.
Clin Physiol Funct Imaging
September 2024
Department of Bioengineering, Imperial College London, London, UK.
Introduction: Investigations of responses of animals and humans to changes of plasma volume are usually reported as average responses of groups of individuals. This ignores considerable quantitative variation between individuals. We examined the hypothesis that individual responses follow a common temporal pattern with variations reflecting different parameters describing that pattern.
View Article and Find Full Text PDFRegulation of myocardial contraction as revealed by intracellular Ca measurements using aequorin.
J Physiol Sci
February 2024
Department of Cell Physiology, The Jikei University School of Medicine, 3-25-8 Nishi-Shimbashi, Minato-Ku, Tokyo, 105-8461, Japan.
Of the ions involved in myocardial function, Ca is the most important. Ca is crucial to the process that allows myocardium to repeatedly contract and relax in a well-organized fashion; it is the process called excitation-contraction coupling. In order, therefore, for accurate comprehension of the physiology of the heart, it is fundamentally important to understand the detailed mechanism by which the intracellular Ca concentration is regulated to elicit excitation-contraction coupling.
View Article and Find Full Text PDFMitochondrial techniques for physiologists.
Comp Biochem Physiol B Biochem Mol Biol
February 2024
Department of Biology, University of Western Ontario, 1151 Richmond Street, London, Ontario, Canada.
Mitochondria serve several important roles in maintaining cellular homeostasis, including adenosine triphosphate (ATP) synthesis, apoptotic signalling, and regulation of both reactive oxygen species (ROS) and calcium. Therefore, mitochondrial studies may reveal insights into metabolism at higher levels of physiological organization. The apparent complexity of mitochondrial function may be daunting to researchers new to mitochondrial physiology.
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