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A systematic review of enrolment criteria and treatment efficacy for microvascular angina.
EuroIntervention
January 2025
National Heart and Lung Institute, Imperial College London, London, United Kingdom.
Background: Microvascular angina (MVA) is an important contributor to morbidity and mortality in patients with non-obstructive coronary artery disease. Despite improvements in its recognition and diagnosis, uncertainty remains around the most effective treatment strategy, and more data are needed.
Aims: We aimed to evaluate the quality of patient selection in treatment studies of MVA and provide a contemporary overview of the evidence base for the treatment of MVA.
Pathological findings at invasive assessment in MINOCA: a systematic review and meta-analysis.
Heart
December 2024
Department of Medical and Surgical Sciences, Alma Mater Studiorum University of Bologna, Bologna, Emilia-Romagna, Italy
Article Synopsis
- The study investigates myocardial infarction with non-obstructive coronary arteries (MINOCA), revealing that its underlying causes are diverse and not well understood in clinical settings.
- A review of 45 studies found that 53% of patients with MINOCA had non-obstructive coronary artery stenosis, with significant findings from optical coherence tomography and vasomotor tests.
- Patients with non-obstructive coronary arteries showed a higher risk of death or myocardial infarction at one year compared to those with normal arteries, indicating the need for better diagnostic methods in understanding MINOCA.
Utilizing Invasive Coronary Functional Testing in a Coronary Microvascular and Vasomotor Dysfunction Program: Methods and Considerations.
Catheter Cardiovasc Interv
December 2024
Carl and Edyth Lindner Center for Research and Education, The Christ Hospital Health Network, Cincinnati, Ohio, USA.
Background: Coronary microvascular and vasomotor dysfunction (CMVD) is associated with a threefold increased risk of major adverse cardiovascular events (MACE) and is the primary mechanism responsible for angina/ischemia in patients with nonobstructive coronary artery disease (ANOCA/INOCA). Proper assessment for CMVD is vital to provide targeted treatment and improve patient outcomes. Invasive coronary functional testing (ICFT) is the "gold standard," for CMVD assessment and can be used to diagnose all endotypes.
View Article and Find Full Text PDFAcute cardiovascular responses of postmenopausal women to resistance training sessions differing in set configuration: A study protocol for a crossover trial.
PLoS One
October 2024
Performance and Health Group, Department of Physical Education and Sport, Faculty of Sports Sciences and Physical Education, University of A Coruna, A Coruña, Spain.
Article Synopsis
- Resistance training is recommended for postmenopausal women to address hormonal changes, but concerns exist regarding high-load exercises' effects on cardiovascular health.
- This study will involve 60 active postmenopausal women (30 healthy, 30 hypertensive) to evaluate how different resistance training set configurations affect various cardiovascular responses.
- The findings will contribute to understanding how resistance training impacts cardiovascular health in postmenopausal women, an area that has been under-researched.
Role of the Kölliker-Fuse/parabrachial complex in the generation of postinspiratory vagal and sympathetic nerve activities and their recruitment by hypoxemic stimuli in the rat.
J Neurophysiol
November 2024
Macquarie Medical School, Faculty of Medicine, Health and Human SciencesMacquarie University, Sydney, Australia.
Article Synopsis
- The study investigates how the Kölliker-Fuse/Parabrachial nuclei (KF-PBN) in rats regulates post-inspiratory (post-I) activities that affect respiratory efficiency during normal conditions and acute hypoxemia.
- When the KF-PBN was inhibited, researchers observed changes such as reduced phrenic nerve activity and abolished post-I vagal responses, indicating its role in managing these respiratory outputs.
- The findings suggest the KF-PBN is crucial for modulating post-I vagal activity but only partially involved in sympathetic nerve activity, implying multiple neural pathways are at play in respiratory-sympathetic coordination during stress.
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