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Synergistic integration of histone deacetylase inhibitors apparently enhances the cytokine-induced killer cell efficiency in multiple myeloma via the NKG2D pathway.
Clin Transl Immunology
March 2024
Department of Integrated Oncology, Center for Integrated Oncology (CIO) Bonn University Hospital Bonn Bonn Germany.
Article Synopsis
- - The study explores the combination of histone deacetylase inhibitors (HDACis) and cytokine-induced killer cell (CIK) immunotherapy as a potential treatment for multiple myeloma (MM), showing promising outcomes in improving cancer cell destruction.
- - Researchers tested HDACis like panobinostat and romidepsin with CIK cells on various MM cell lines, discovering that this combination boosted CIK cell cytotoxicity and increased markers related to apoptosis and antitumor activity.
- - The findings suggest that enhancing NKG2D/NKG2D-ligand interactions may be key in improving the effectiveness of CIK cells against myeloma cells when treated with HDACis, highlighting a potential
Histone H1, the forgotten histone.
Epigenomics
February 2019
Institute of Functional Epigenetics, Helmholtz Zentrum München, 85764 Neuherberg, Germany.
Inhibitory effect of valproate sodium on pain behavior in diabetic mice involves suppression of spinal histone deacetylase 1 and inflammatory mediators.
Int Immunopharmacol
May 2019
Department of Pharmacology and Toxicology, Faculty of Pharmacy, University of Tabuk, Tabuk, Saudi Arabia; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Suez Canal University, Ismailia, Egypt. Electronic address:
Anti-epileptic medications are included in the international guidelines for managing neuropathic pain. Valproate sodium (VPS) was recently described as "the forgotten analgesic" and has been reported to relief pain in various models of neuropathic pain. Some studies reported anti-inflammatory and histone deacetylase 1 (HDA1) inhibitory properties for sodium valproate.
View Article and Find Full Text PDFThe forgotten class of drugs for multiple myeloma: HDAC inhibitors.
Lancet Haematol
December 2018
John Theurer Cancer Center at Hackensack University Medical Center, and Hackensack Meridian School of Medicine at Seton Hall University, Hackensack, NJ 07601, USA.
The genetics underlying natural variation of plant-plant interactions, a beloved but forgotten member of the family of biotic interactions.
Plant J
February 2018
LIPM, Université de Toulouse, INRA, CNRS, Castanet-Tolosan, France.
Despite the importance of plant-plant interactions on crop yield and plant community dynamics, our understanding of the genetic and molecular bases underlying natural variation of plant-plant interactions is largely limited in comparison with other types of biotic interactions. By listing 63 quantitative trait loci (QTL) mapping and global gene expression studies based on plants directly challenged by other plants, we explored whether the genetic architecture and the function of the candidate genes underlying natural plant-plant interactions depend on the type of interactions between two plants (competition versus commensalism versus reciprocal helping versus asymmetry). The 16 transcriptomic studies are unevenly distributed between competitive interactions (n = 12) and asymmetric interactions (n = 4, all focusing on response to parasitic plants).
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