AI Article Synopsis
- The study aimed to validate a retinal imaging software called VAMPIRE for use in cats, particularly focusing on hypertensive patients.
- It involved 105 healthy cats for baseline data and 43 hypertensive cats without visible retinal issues to assess the software's clinical utility.
- Results showed significant differences in arteriolar diameters and angles between healthy and hypertensive cats, suggesting that VAMPIRE could be a valuable tool for diagnosing hypertension-related retinal changes in feline patients.
Article Abstract
Objectives: To validate a retinal imaging software named VAMPIRE (Vascular Assay and Measurement Platform for Images of the Retina) in feline patients and test the clinical utility in hypertensive cats.
Animals Studied: One hundred and five healthy cats were enrolled. They represented the normal dataset used in the validation (group 1). Forty-three hypertensive cats with no noticeable retinal abnormalities were enrolled for the clinical validity of the software (group 2).
Procedures: Eleven points (4 veins, 4 arteries, and 3 arterial bifurcations) were measured for each digital image. Repeatability and reproducibility of measurements were assessed using two independent operators. Data were statistically analyzed by the Mann-Whiney and Tukey box plot. Significance was considered when P < 0.05.
Results: Two hundred and ten retinal images were analyzed for a total of 2310 measurements. Total mean was 9.1 and 6.1 pixels for veins and arteries, respectively. First, second, and third arteriolar bifurcations angles were 73.6°, 76.9°, and 85.4°, respectively. A comparison between groups 1 and 2 showed a statistically significant reduction in arteriolar diameter (mean 3.3 pixels) and branch angle (55°, 47.8° and 59.9°) associated with increasing vein diameter (mean 24.15 pixels).
Conclusions: Current image analysis techniques used in human medicine were investigated in terms of extending their use to veterinary medicine. The VAMPIRE algorithm proved useful for an objective diagnosis of retinal vasculature changes secondary to systemic hypertension in cats, and could be an additional diagnostic test for feline systemic hypertension.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1111/vop.12657 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Cardiac pathology associated with hypertension and chronic kidney disease in aged cats.
J Comp Pathol
January 2025
Department of Comparative Biomedical Sciences, Royal Veterinary College, University of London, Royal College Street, London NW1 0TU, UK. Electronic address:
Hypertension is a common condition in older cats, often secondary to chronic kidney disease (CKD). Although the heart is one of the organs damaged by hypertension, the pathology of the feline hypertensive (HT) heart has been poorly studied. The aim of this retrospective study was to describe the gross and microscopic pathology of hearts obtained from cats at post-mortem examination and to compare cats diagnosed with hypertension with cats of similar age and kidney function for which antihypertensive treatment was not deemed clinically necessary.
View Article and Find Full Text PDFThe renin-angiotensin-aldosterone system in kidney diseases of cats and dogs.
Vet J
December 2024
Department of Small Animal Medicine and Surgery, University of Georgia, College of Veterinary Medicine, Athens 30601, USA.
The renin-angiotensin-aldosterone system (RAAS) has a well-established key pathophysiologic role in kidney diseases, and pharmacotherapy targeting this system is a mainstay of treatment of affected human beings, cats, and dogs. Several studies have evaluated the circulating RAAS in animals with spontaneous or experimentally induced kidney diseases. Evidence supporting the activation of this system has been demonstrated in some - but not all - studies and individuals, and the interindividual variability in circulating RAAS markers is high.
View Article and Find Full Text PDFClinical Significance of Coronary Artery Tortuosity in Chronic Coronary Syndrome and Stable Angina: Insights from Gensini Scores.
Turk Kardiyol Dern Ars
December 2024
İstanbul Health and Technology University, Sisli Kolan Hospital, İstanbul, Türkiye.
Objective: This study investigated the clinical significance of coronary artery tortuosity (CAT) in chronic coronary syndrome (CCS) using Gensini scores.
Method: This retrospective single-center study involved 388 patients undergoing coronary angiography for chest pain, excluding those with acute coronary syndromes or prior coronary interventions. Demographic, clinical, and angiographic data were collected and categorized based on the presence or absence of CAT.
Perioperative anaesthetic complications in healthy cats undergoing anaesthesia for neutering in first opinion practice.
J Feline Med Surg
October 2024
School of Biodiversity, One Health and Veterinary Medicine, University of Glasgow, UK.
Objectives: The aim of the present study was to identify the incidence of common perioperative anaesthetic complications in cats undergoing anaesthesia for neutering in three UK first opinion practices.
Methods: A retrospective anaesthetic record analysis was performed on cats anaesthetised for neutering at practices 1 and 2 between 9 December 2017 and 2 February 2021 and practice 3 between 9 March 2020 and 7 January 2021. A search of the practice management system identified all cats that had undergone neutering in the selected timeframe.
Somatic , , and Mutations in Cat Aldosterone-Secreting Tumors.
Hypertension
December 2024
Clinical Pharmacology and Precision Medicine, Queen Mary University of London, United Kingdom (A.W., M.B.).
Article Synopsis
- - Primary aldosteronism (PA) is a major cause of high blood pressure in humans, often linked to specific gene mutations in adrenal tumors, and studying these mutations in cats may provide insights into adrenal gland function and PA.
- - In a study of 13 cats with aldosterone-secreting tumors, researchers used advanced DNA and RNA sequencing techniques to identify mutations that likely affect protein function and contribute to aldosterone secretion.
- - The study found mutations in genes common to both cats and humans with PA, suggesting shared evolutionary pressures leading to increased aldosterone secretion, despite differences in gene expression levels between the two species.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!