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George Gomori's Contributions to Diabetes Research and the Origins of the .
J Histochem Cytochem
December 2024
Division of Metabolism, Endocrinology, and Nutrition, Department of Medicine, University of Washington, Seattle, Washington (DGB).
Article Synopsis
- Gomori was a key figure in enzyme histochemistry for nearly 30 years, pioneering methods to demonstrate enzyme activity, especially phosphatases, esterases, and lipases.
- He made significant strides in diabetes research by creating histological techniques that effectively stained insulin-secreting B cells in the pancreas, which were crucial for understanding the disease.
- As a founding member and President of The Histochemical Society, Gomori played a pivotal role in advancing the field, including serving as one of the first Associate Editors for the society's journal.
Positron emission tomography-magnetic resonance imaging applications in pediatric musculoskeletal tumors.
Quant Imaging Med Surg
November 2024
Radiology Unit, Alcorcon Foundation University Hospital, Alcorcon, Madrid, Spain.
Background: The hybrid imaging positron emission tomography/magnetic resonance (PET/MR) is an important tool in the management of pediatric oncology patients, particularly in malignant musculoskeletal pathologies, because it combines the functional and metabolic information of tumor provided by PET with the high soft-tissue contrast and the functional information offered by magnetic resonance imaging (MRI).
Methods: We performed an observational retrospective study that included pediatric patients diagnosed with primary bone or soft-tissue sarcomas in the Pediatric Hematology and Oncology Unit at the HM Montepríncipe University Hospital, Boadilla del Monte, Madrid (Spain) who underwent whole-body F-fluorodeoxyglucose (F-FDG) PET/MRI as a staging study and for follow-up evaluation for treatment response from September 2017 to January 2023. This study explores the protocols, the practical application of the PET/MRI technique and our clinical experience at our center in the diagnosis and follow-up of primary bone tumors and soft-tissue sarcomas in children.
Ex-CyT-ing Applications of Single-cell CyTOF to Human Pancreatic Islets in Diabetes Research.
Endocrinology
September 2024
Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, SC 29425, USA.
Extracellular vesicles derived from stressed beta cells mediate monocyte activation and contribute to islet inflammation.
Front Immunol
August 2024
Department of Cell and Chemical Biology, Leiden University Medical Center, Leiden, Netherlands.
Objective: Beta cell destruction in type 1 diabetes (T1D) results from the combined effect of inflammation and recurrent autoimmunity. In recent years, the role played by beta cells in the development of T1D has evolved from passive victims of the immune system to active contributors in their own destruction. We and others have demonstrated that perturbations in the islet microenvironment promote endoplasmic reticulum (ER) stress in beta cells, leading to enhanced immunogenicity.
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