AI Article Synopsis
- The study aimed to assess how the combination of hepatic venous pressure gradient (HVPG) and liver stiffness (LS) affects long-term mortality in patients with cirrhosis.
- Data was gathered from 103 cirrhosis patients by measuring HVPG and LS, categorizing them into four groups, and analyzing their mortality outcomes over a median follow-up of 47.3 months.
- Patients with both high HVPG and high LS had significantly higher mortality rates compared to those in other groups, highlighting that elevated levels of both measurements together are critical indicators of increased risk.
Article Abstract
Background/aims: Both hepatic venous pressure gradient (HVPG) and liver stiffness (LS) are useful tools for predicting mortality in patients with cirrhosis. We investigated the combined effect of HVPG and LS on long-term mortality in patients with cirrhosis.
Methods: We retrospectively collected data from 103 patients with cirrhosis, whose HVPG and LS were measured between November 2009 and September 2013. The patients were divided into four groups according to the results of the HVPG and LS measurements. Long-term mortality and the risk factors for mortality were analyzed.
Results: Of the 103 patients, 35 were in group 1 (low HVPG and low LS), 16 in group 2 (high HVPG and low LS), 24 in group 3 (low HVPG and high LS), and 28 in group 4 (high HVPG and high LS). Over a median follow-up of 47.3 months, 18 patients died. The mortality rate of patients in group 4 was significantly higher than in the other three groups (vs. group 1, p = 0.005; vs. group 2, p = 0.049; vs. group 3, p = 0.004), but there were no significant differences in survival between groups 1, 2, and 3. In multivariable analyses, both HVPG and LS were identified as independent risk factors for mortality (hazard ratio [HR], 1.127, p = 0.018; and HR, 1.062, p = 0.009, respectively).
Conclusion: In patients with cirrhosis, those with concurrent elevation of HVPG and LS had the highest long-term mortality rates. However, when either HVPG or LS alone was elevated, mortality did not increase significantly.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6960044 | PMC |
| http://dx.doi.org/10.3904/kjim.2018.151 | DOI Listing |
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