Hough Transform (HT), which has a low sensitivity to local faults and good ability in suppressing noise and clutters, usually applies to trajectory detection in a cluttered environment. This paper describes its application for detecting the trajectories of extended targets in three-dimensional measurements, i.e., a two-dimensional positional information and its measuring time. For taking the full merits of a multi-scan, the measuring time is regarded as a variable for the time axis. This correspondence extends the HT to 3-dimensional data. Meanwhile, a three-dimensional accumulator matrix is built for the purpose of voting. The voting process is done in an iterative way by selecting the 3D-line with the most votes and removing the corresponding measurements in each step. The three dimensional Hough Transform-based extended target track-before-detect technique (3DHT-ET-TBD), proposed here, is suitable to track the extended target and non-extended target simultaneously and few false alarm trajectories arise. Both the real data and simulated data are exploited to evaluate its performance. Compared with the Gaussian Mixture Probability Hypothesis Density (GM-PHD) filter based methods and a 4DHT-TBD algorithm, the 3DHT-ET-TBD is a more promising approach for multi-extended target tracking problems due to its high efficiency and low computation, especially in situations where the noise and false alarms are considerably high but few measurements are generated by the extended targets.
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http://dx.doi.org/10.3390/s19040881 | DOI Listing |
Front Med (Lausanne)
December 2024
Department of Ophthalmology, Affiliated Eye Hospital of Shandong University of Traditional Chinese Medicine, Jinan, China.
Background: Pulmonary arterial hypertension (PAH) is characterized by elevated pulmonary artery pressure and vascular resistance, leading to systemic venous hypertension and potential right heart failure. These elevated pressures can extend to ocular veins, resulting in complications such as central retinal vein occlusion (CRVO). This case report highlights a rare instance of CRVO combined with cilioretinal artery occlusion (CilRAO), an uncommon ocular manifestation associated with PAH.
View Article and Find Full Text PDFTurk J Biol
October 2024
Department of Genetics and Bioengineering, Faculty of Engineering, Yeditepe University, İstanbul, Turkiye.
MEIS1, a member of the TALE-type homeobox gene family, has emerged as a pivotal regulator of cardiomyocyte cell cycle arrest and represents a promising therapeutic target. Our study reveals that inhibition of MEIS1 using two novel small molecules, MEISi-1 and MEISi-2, significantly enhances neonatal cardiomyocyte proliferation and cytokinesis. Specifically, MEISi-1 and MEISi-2 increased the proportion of proliferating cardiomyocytes (Ph3+TnnT cells) up to 4.
View Article and Find Full Text PDFZhonghua Jie He He Hu Xi Za Zhi
January 2025
National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou510120, China.
This paper reviews the clinical progress achieved in 2024 in the field of advanced non-small cell lung cancer (NSCLC), both nationally and internationally. In the area of targeted therapy, particularly for rare mutations, new targets beyond EGFR, ALK, and ROS1 mutations, such as KRAS G12C, HER2, and MET, have gained more clinical validation and approval for targeted drugs in 2024. KRAS G12C inhibitors have also shown significant improvements in disease control rates for patients.
View Article and Find Full Text PDFJ Atheroscler Thromb
December 2024
Victorian Heart Institute, Monash University.
Atherosclerotic cardiovascular disease (ASCVD) is a leading global cause of mortality, and recent research has underscored the critical role of lipoproteins in modulating cardiovascular (CV) risk. Elevated low-density lipoprotein cholesterol (LDL-C) levels have been linked to increased CV events, and while numerous trials have confirmed the efficacy of lipid-lowering therapies (LLT), significant gaps remain between recommended LDL-C targets and real-world clinical practice. This review addresses care gaps in LLT, emphasizing the necessity for innovative approaches that extend beyond LDL-C management.
View Article and Find Full Text PDFBiosens Bioelectron
December 2024
Department of Gastroenterology, Hubei Key Laboratory of Tumor Biological Behavior, Zhongnan Hospital of Wuhan University, Wuhan, 430072, PR China; Research Institute of Shenzhen, Wuhan University, Shenzhen, 518057, PR China. Electronic address:
Biomolecules play essential roles in regulating the orderly progression of biochemical reaction networks. DNA-based biocircuits supplement an attractive and ideal approach for the visual imaging of endogenous biomolecules, yet their sensing performance is commonly encumbered by the undesired signal leakage. To solve this issue, here we proposed a glutathione (GSH)-activated DNA circuit for achieving the spatio-selective microRNA imaging through the successive response of a GSH-specific activation procedure and a non-enzymatic catalytic signal amplification procedure.
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