AI Article Synopsis
- Dietary restriction, which involves limiting calories or specific nutrients, is currently the only non-genetic method known to significantly increase lifespan across various organisms, from yeast to mammals.
- Recent studies focused on the budding yeast, Saccharomyces cerevisiae, are shedding light on the genetic mechanisms that contribute to longevity under dietary restriction, but a detailed genome-wide analysis is still lacking.
- Advancements in high-throughput techniques to analyze yeast lifespan are enhancing our knowledge of how dietary restriction affects longevity and the cellular interactions related to nutrient sensing.
Article Abstract
Dietary restriction-limitation of calories or other specific nutrients in the diet-is the sole non-genetic intervention known to extend the lifespan of a wide range of model organisms from yeast to mammals. Cell biology studies on the responses to dietary restriction have provided important clues about the mechanisms of longevity; however, a comprehensive genome-wide description of lifespan by dietary restriction has been mostly absent. Large-scale genetic analysis in the budding yeast Saccharomyces cerevisiae offers a great opportunity to uncover the conserved systems-level mechanisms that give way to longevity in response to diet. Here, we review recent advances in high-throughput phenotyping of the replicative and chronological life spans of yeast cells, which have contributed to our understanding of longevity by dietary restriction and the cellular crosstalks of nutrient-sensing regulation.
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| http://dx.doi.org/10.1016/j.mad.2019.02.003 | DOI Listing |
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