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Involvement of necroptosıs and apoptosıs ın protectıve effects of cyclosporın a on ischemıa-reperfusıon injury in rat kıdney.
J Mol Histol
December 2024
Department of Pharmacology, School of Medicine, Uskudar University, Istanbul, Turkey.
Article Synopsis
- The study examined how low dose cyclosporin A (CsA) can protect rat kidneys from damage caused by ischemia-reperfusion (IR) injury, focusing on mechanisms of cell death.
- Three groups were tested: a control group, an IR group (exposed to restricted blood flow), and an IR + CsA group (received CsA before the IR procedure).
- Results showed that CsA significantly improved kidney function and reduced injury markers compared to the IR group, indicating its protective effects against IR-related kidney damage.
Late-onset tacrolimus-induced encephalopathy in lung transplant recipient: Case report.
Heliyon
November 2024
State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, National Center for Respiratory Medicine, Department of Organ transplantation, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, 510120, PR China.
Article Synopsis
- * A case study of a 61-year-old woman showed confusion and muscle stiffness 29 months post-lung transplant, revealing a diagnosis of tacrolimus-induced encephalopathy despite normal drug levels in her blood.
- * After switching her treatment from tacrolimus to cyclosporine, her neurological symptoms improved, indicating that tacrolimus was the cause of her condition, even when drug levels were considered safe.
Induced pluripotent stem-cell-derived corneal epithelium for transplant surgery: a single-arm, open-label, first-in-human interventional study in Japan.
Lancet
November 2024
Department of Ophthalmology, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan; Integrated Frontier Research for Medical Science Division, Institute for Open and Transdisciplinary Research Initiatives, Osaka University, Suita, Osaka, Japan; Premium Research Institute for Human Metaverse Medicine, Osaka University, Suita, Osaka, Japan. Electronic address:
Background: The loss of corneal epithelial stem cells from the limbus at the edge of the cornea has severe consequences for vision, with the pathological manifestations of a limbal stem-cell deficiency (LSCD) difficult to treat. Here, to the best of our knowledge, we report the world's first use of corneal epithelial cell sheets derived from human induced pluripotent stem cells (iPSCs) to treat LSCD.
Methods: This non-randomised, single-arm, clinical study involved four eyes of four patients with LSCD at the Department of Ophthalmology, Osaka University Hospital.
Comparison of a voclosporin-based triple immunosuppressive therapy to high-dose glucocorticoid-based immunosuppressive therapy: a propensity analysis of the AURA-LV and AURORA 1 studies and ALMS.
Lupus Sci Med
November 2024
Columbia University College of Physicians and Surgeons, New York, New York, USA.
Article Synopsis
- High-dose glucocorticoid (GC)-based treatments for lupus nephritis are common but can cause significant side effects and are not always fully effective; this study explored the impact of adding voclosporin to a low-dose GC regimen.* -
- Participants were matched from two study groups: those receiving voclosporin with low-dose GCs and mycophenolate mofetil (MMF), and those on high-dose GCs with MMF and intravenous cyclophosphamide (IVC); safety and efficacy were evaluated over 6 months.* -
- Results indicated that the voclosporin group experienced fewer adverse events and achieved better reductions in urine protein levels compared to those receiving high-dose GCs
Non-corticosteroid immunosuppressive medications for steroid-sensitive nephrotic syndrome in children.
Cochrane Database Syst Rev
November 2024
Cochrane Kidney and Transplant, Centre for Kidney Research, The Children's Hospital at Westmead, Westmead, Australia.
Background: About 80% of children with steroid-sensitive nephrotic syndrome (SSNS) have relapses. Of these children, half will relapse frequently, and are at risk of adverse effects from corticosteroids. While non-corticosteroid immunosuppressive medications prolong periods of remission, they have significant potential adverse effects.
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