AI Article Synopsis
- The study investigates the health effects of ultrafine particles (UFP) and aims to review recent literature published since 2013.
- Researchers searched MEDLINE and LUDOK for studies from 2011 to 2017, identifying 85 relevant investigations, mostly focusing on short-term health effects.
- The results indicate significant short-term adverse effects on inflammation, heart rate variability, and blood pressure, while the impact of UFP on other health outcomes remains unclear.
Article Abstract
Objectives: Due to their small size, ultrafine particles (UFP) are believed to exert higher toxicity than larger particles. As numerous studies on health effects of UFP have been published since the last systematic review in 2013, we aim to systematically review the new literature.
Methods: We searched MEDLINE and the specialized LUDOK database for studies published between 01.01.2011 and 11.05.2017 investigating health effects of ambient air pollution-related UFP. We included epidemiologic studies containing UFP measures and quantifiable measures of associations. Relevant data were extracted on the basis of previously developed evaluation criteria.
Results: We identified 85 original studies, conducting short-term (n = 75) and long-term (n = 10) investigations. Panel (n = 32), scripted exposure with predefined settings (n = 16) or time series studies (n = 11) were most frequent. Thirty-four studies adjusted for at least one other pollutant. Most consistent associations were identified for short-term effects on pulmonary/systemic inflammation, heart rate variability and blood pressure.
Conclusions: The evidence suggests adverse short-term associations with inflammatory and cardiovascular changes, which may be at least partly independent of other pollutants. For the other studied health outcomes, the evidence on independent health effects of UFP remains inconclusive or insufficient.
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| http://dx.doi.org/10.1007/s00038-019-01202-7 | DOI Listing |
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