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| http://dx.doi.org/10.1371/journal.pntd.0007020 | DOI Listing |
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Neuronal traveling waves form preferred pathways using synaptic plasticity.
J Comput Neurosci
December 2024
Department of Physics, Drexel University, 3141 Chestnut Street, Philadelphia, 19104, PA, USA.
Traveling waves of neuronal spiking activity are commonly observed across the brain, but their intrinsic function is still a matter of investigation. Experiments suggest that they may be valuable in the consolidation of memory or learning, indicating that consideration of traveling waves in the presence of plasticity might be important. A possible outcome of this consideration is that the synaptic pathways, necessary for the propagation of these waves, will be modified by the waves themselves.
View Article and Find Full Text PDFModulation of the Magnetic Anisotropy via the Ligand Field in Sandwiched Erbium Complexes.
Inorg Chem
December 2024
Institute of Nano Science and Technology, Sector-81, Mohali, Punjab 140306, India.
Among lanthanide-based single-molecule magnets (SMMs), erbium(III) is a Kramers ion, apart from dysprosium(III), which provides magnetic bistability in the presence of a suitable coordination environment. However, Er-based SMMs exhibit significantly less magnetic anisotropy than Dy because their prolate electronic density necessitates equatorially correlated ligands to minimize the charge contact with the Er atom. Here, in this work, we have computationally investigated the heteroleptic organometallic complexes with an Er(III) atom sandwiched between two distinct cyclic rings (five- and eight-membered) with the aim of tuning the magnetic anisotropy via exploiting the ligand field.
View Article and Find Full Text PDFInterobserver Variability in Manual Versus Semi-Automatic CT Assessments of Small Lung Nodule Diameter and Volume.
Tomography
December 2024
Centre for Research and Development, Uppsala University, Region Gävleborg, SE 801 88 Gävle, Sweden.
Background: This study aimed to assess the interobserver variability of semi-automatic diameter and volumetric measurements versus manual diameter measurements for small lung nodules identified on computed tomography scans.
Methods: The radiological patient database was searched for CT thorax examinations with at least one noncalcified solid nodule (∼3-10 mm). Three radiologists with four to six years of experience evaluated each nodule in accordance with the Fleischner Society guidelines using standard diameter measurements, semi-automatic lesion diameter measurements, and volumetric assessments.
To Change or Not to Change: Perceptions and Experiential Knowledge of Tennis Coaches When Modifying Grip Technique.
Sports (Basel)
November 2024
Sport, Performance, and Nutrition Research Group, School of Allied Health, Human Services and Sport, La Trobe University, 1 Kingsbury Drive, Bundoora, Melbourne, VIC 3083, Australia.
The purpose of this study was to explore the experiential knowledge of tennis coaches as it related to the development of grip positions in tennis athletes. Accredited tennis coaches (n = 11) completed semi-structured interviews consisting of open-ended questions about their coaching background, the importance of grip positions compared with other areas of foundational development, and their opinions on using physically-constraining tools (PCTs). Two major themes, "Grip positions are an adaptive skill" and "Why and how do I modify an athlete's grip?", were identified.
View Article and Find Full Text PDFEstablishment of Stable Knockdown of MACC1 Oncogene in Patient-Derived Ovarian Cancer Organoids.
Methods Protoc
December 2024
Department of Obstetrics and Gynecology, University Hospital, Ludwig-Maximilians-University Munich, 81377 Munich, Germany.
High-grade serous ovarian cancer (HGSOC) remains the most lethal gynecological malignancy, and there is still an unmet medical need to deepen basic research on its origins and mechanisms of progression. Patient-derived organoids of high-grade serous ovarian cancer (HGSOC-PDO) are a powerful model to study the complexity of ovarian cancer as they maintain, in vitro, the mutational profile and cellular architecture of the cancer tissue. Genetic modifications by lentiviral transduction allow novel insights into signaling pathways and the potential identification of biomarkers regarding the evolution of drug resistance.
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