AI Article Synopsis
- The review highlights the significance of long noncoding RNAs (lncRNAs) in heart failure and cardiovascular diseases.
- Recent research shows that lncRNAs contribute to various cardiac functions, including regeneration and hypertrophy, by interacting with MicroRNAs and proteins.
- Understanding lncRNAs could unveil new therapeutic approaches for treating cardiovascular diseases, emphasizing the need for further research into their specific mechanisms.
Article Abstract
Purpose Of Review: Human genome is pervasively transcribed, producing coding and noncoding RNAs. Recent studies have revealed the roles of a class of noncoding RNAs, the long noncoding RNAs (lncRNAs), in heart failure and other cardiovascular diseases. This review provides a brief summary of recent findings on lncRNA function.
Recent Findings: Recent studies have documented the roles of lncRNAs in cardiac regeneration, conduction, hypertrophy/dysfunction, and endothelial function. LncRNAs perform these functions through acting as competing RNA (by binding and sequestering MicroRNAs) or acting as guides to protein targeting. A few lncRNAs also encode small peptides (e.g., Dwarf Open Reading Frame RNA) and in the context of heart regulate cardiac calcium homeostasis.
Summary: Noncoding RNA provides a versatile mechanism of gene regulation and thereby present as novel targets for intervention in various cardiovascular disease. Future studies aimed at defining the context-dependent lncRNA mechanisms will be required to advance our understanding and relish the goal of RNA therapeutics.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6459692 | PMC |
| http://dx.doi.org/10.1097/HCO.0000000000000615 | DOI Listing |
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