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PLCOjs, a FAIR GWAS web SDK for the NCI Prostate, Lung, Colorectal and Ovarian Cancer Genetic Atlas project.
Bioinformatics
September 2022
Division of Cancer Epidemiology and Genetics (DCEG), National Cancer Institute, Rockville, MD 20850, USA.
Article Synopsis
- - The National Cancer Institute's DCEG and DCP developed GWAS data from 110,000 participants in the PLCO Genomic Atlas project, aiming to share this data through a portal called GWAS Explorer, meeting data scientists' and engineers' needs for fair data access.
- - The PLCO GWAS Explorer uses a stateless API for its backend, allowing users to access the data through a web application and integrate with other analytical tools without installation.
- - The core of the project includes the PLCOjs SDK, which links to the API and provides various visualization methods; the project's code and resources are available on GitHub.
Association and mechanism of garlic consumption with gastrointestinal cancer risk: A systematic review and meta-analysis.
Oncol Lett
April 2022
School of Medicine, Cheeloo College of Medicine, Shandong University, Jinan, Shandong 250012, P.R. China.
Gastrointestinal cancer is one of the most commonly diagnosed cancer type worldwide, with millions of cases per year. The aim of this review was to investigate the relationship between garlic intake and the risk reduction of gastrointestinal cancer. We performed saturated data mining on various public domain databases, including PubMed (https://pubmed.
View Article and Find Full Text PDFSensitive detection of colorectal cancer in peripheral blood by a novel methylation assay.
Clin Epigenetics
April 2021
AnchorDx Medical Co., Ltd, Unit 502, 3rd Luoxuan Road, International Bio-Island, Guangzhou, 510300, China.
Background: Colorectal cancer (CRC) is a leading cause of cancer-related deaths worldwide. Early detection of CRC can significantly reduce its mortality rate. Current method of CRC diagnosis relies on the invasive endoscopy.
View Article and Find Full Text PDFIdentifying potential DNA methylation markers in early-stage colorectal Cancer.
Genomics
September 2020
Department of Pathology, School of Basic Medical Science, Southern Medical University, Guangzhou, 510515, China; AnchorDx Medical Co., Ltd, Unit 502, 3(rd) Luoxuan Road, International Bio-Island, Guangzhou, 510300, China. Electronic address:
Colorectal cancer (CRC) is the second leading malignancy worldwide. Accurate screening is pivotal to early CRC detection, yet current screening modality involves invasive colonoscopy while non-invasive FIT tests have limited sensitivity. We applied a DNA methylation assay to identify biomarkers for early-stage CRC detection, risk stratification and precancerous lesion screening at tissue level.
View Article and Find Full Text PDFLanding Your First Colorectal Surgery Job: How to Find It and What to Expect.
Dis Colon Rectum
May 2019
Department of Surgery, University Hospitals Cleveland Medical Center, Cleveland, Ohio.
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