The original version of this Article contained an error in the spelling of the author Anna K Radke, which was incorrectly given as Anna R Radke. This has now been corrected in both the PDF and HTML versions of the Article.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6461880 | PMC |
| http://dx.doi.org/10.1038/s41386-019-0331-x | DOI Listing |
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Mu-opioid receptor knockout on Foxp2-expressing neurons reduces aversion-resistant alcohol drinking.
Pharmacol Biochem Behav
December 2024
Department of Psychology and Center for Neuroscience and Behavior, Miami University, Oxford, OH, USA. Electronic address:
Mu-opioid receptors (MORs) in the amygdala and striatum are important in addictive and rewarding behaviors. The transcription factor Foxp2 is a genetic marker of intercalated (ITC) cells in the amygdala and a subset of striatal medium spiny neurons (MSNs), both of which express MORs in wild-type mice and are neuronal subpopulations of potential relevance to alcohol-drinking behaviors. For the current series of studies, we characterized the behavior of mice with genetic deletion of the MOR gene Oprm1 in Foxp2-expressing neurons (Foxp2-Cre/Oprm1).
View Article and Find Full Text PDFCholinergic mu-opioid receptor deletion alters reward preference and aversion-resistance.
Neuropharmacology
September 2024
Department of Psychology and Center for Neuroscience and Behavior, Miami University, Oxford, OH, USA. Electronic address:
The endogenous opioid system has been implicated in alcohol consumption and preference in both humans and animals. The mu opioid receptor (MOR) is expressed on multiple cells in the striatum, however little is known about the contributions of specific MOR populations to alcohol drinking behaviors. The current study used mice with a genetic deletion of MOR in cholinergic cells (ChAT-Cre/Oprm1) to examine the role of MORs expressed in cholinergic interneurons (CINs) in home cage self-administration paradigms.
View Article and Find Full Text PDFMu-opioid receptors (MORs) in the amygdala and striatum are important in addictive and rewarding behaviors. The transcription factor Foxp2 is a genetic marker of intercalated (ITC) cells in the amygdala and a subset of striatal medium spiny neurons (MSNs), both of which express MORs in wild-type mice and are neuronal subpopulations of potential relevance to alcohol-drinking behaviors. For the current series of studies, we characterized the behavior of mice with genetic deletion of the MOR gene Oprm1 in Foxp2-expressing neurons (Foxp2-Cre/Oprm1fl/fl).
View Article and Find Full Text PDFHeavy alcohol use and binge drinking are important contributors to alcohol use disorder (AUD). The endogenous opioid system has been implicated in alcohol consumption and preference in both humans and animals. The mu opioid receptor (MOR) is expressed on multiple cells in the striatum, however little is known about the contributions of specific MOR populations to alcohol drinking behaviors.
View Article and Find Full Text PDFRemoval of the ovaries suppresses ethanol drinking and promotes aversion-resistance in C57BL/6J female mice.
Psychopharmacology (Berl)
December 2023
Department of Psychology and Center for Neuroscience and Behavior, Miami University, 90 N Patterson Ave, Oxford, OH, 45056, USA.
Rationale: Female rodents consume more ethanol (EtOH) than males and exhibit greater aversion-resistant drinking in some paradigms. Ovarian hormones promote EtOH drinking but the contribution of ovarian hormones to aversion-resistant drinking has not been assessed.
Objectives: We aimed to investigate the role of ovarian hormones to aversion-resistant drinking in female mice in a drinking in the dark (DID) task.
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